| http://purl.uniprot.org/citations/25215520 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/25215520 | http://www.w3.org/2000/01/rdf-schema#comment | "Calcium ions (Ca(2+)) function as universal second messengers in eukaryotic cells, including immune cells. Ca(2+) is crucial for peripheral T-lymphocyte activation and effector functions, and influences thymocyte selection and motility in the developing thymus. However, the role of Ca(2+) signalling in early T-lymphocyte development is not well understood. Here we show that the inositol triphosphate receptors (IP3Rs) Ca(2+) ion channels are required for proliferation, survival and developmental progression of T-lymphocyte precursors. Our studies indicate that signalling via IP3Rs represses Sox13, an antagonist of the developmentally important transcription factor Tcf-1. In the absence of IP3R-mediated Ca(2+) signalling, repression of key Notch transcriptional targets--including Hes1--fail to occur in post β-selection thymocytes, and mice develop aggressive T-cell malignancies that resemble human T-cell acute lymphoblastic leukemia (T-ALL). These data indicate that IP3R-mediated Ca(2+) signalling reinforces Tcf-1 activity to both ensure normal development and prevent thymocyte neoplasia."xsd:string |
| http://purl.uniprot.org/citations/25215520 | http://purl.org/dc/terms/identifier | "doi:10.1038/ncomms5814"xsd:string |
| http://purl.uniprot.org/citations/25215520 | http://purl.uniprot.org/core/author | "Chen J."xsd:string |
| http://purl.uniprot.org/citations/25215520 | http://purl.uniprot.org/core/author | "Peng X."xsd:string |
| http://purl.uniprot.org/citations/25215520 | http://purl.uniprot.org/core/author | "Tang H."xsd:string |
| http://purl.uniprot.org/citations/25215520 | http://purl.uniprot.org/core/author | "Fang X."xsd:string |
| http://purl.uniprot.org/citations/25215520 | http://purl.uniprot.org/core/author | "Traver D."xsd:string |
| http://purl.uniprot.org/citations/25215520 | http://purl.uniprot.org/core/author | "Evans S.M."xsd:string |
| http://purl.uniprot.org/citations/25215520 | http://purl.uniprot.org/core/author | "Stachura D.L."xsd:string |
| http://purl.uniprot.org/citations/25215520 | http://purl.uniprot.org/core/author | "Ouyang K."xsd:string |
| http://purl.uniprot.org/citations/25215520 | http://purl.uniprot.org/core/author | "Leandro Gomez-Amaro R."xsd:string |
| http://purl.uniprot.org/citations/25215520 | http://purl.uniprot.org/core/date | "2014"xsd:gYear |
| http://purl.uniprot.org/citations/25215520 | http://purl.uniprot.org/core/name | "Nat Commun"xsd:string |
| http://purl.uniprot.org/citations/25215520 | http://purl.uniprot.org/core/pages | "4814"xsd:string |
| http://purl.uniprot.org/citations/25215520 | http://purl.uniprot.org/core/title | "Loss of IP3R-dependent Ca2+ signalling in thymocytes leads to aberrant development and acute lymphoblastic leukemia."xsd:string |
| http://purl.uniprot.org/citations/25215520 | http://purl.uniprot.org/core/volume | "5"xsd:string |
| http://purl.uniprot.org/citations/25215520 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/25215520 |
| http://purl.uniprot.org/citations/25215520 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/25215520 |
| http://purl.uniprot.org/uniprot/#_A0A0N4SVN2-mappedCitation-25215520 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25215520 |
| http://purl.uniprot.org/uniprot/#_A0A0N4SW22-mappedCitation-25215520 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25215520 |
| http://purl.uniprot.org/uniprot/#_A0A0N4SWH7-mappedCitation-25215520 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25215520 |
| http://purl.uniprot.org/uniprot/#_A0A0N4SWI0-mappedCitation-25215520 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25215520 |
| http://purl.uniprot.org/uniprot/#_A0A1D5RLA1-mappedCitation-25215520 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25215520 |
| http://purl.uniprot.org/uniprot/#_A0A0N4SUL2-mappedCitation-25215520 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25215520 |