| http://purl.uniprot.org/citations/25216678 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/25216678 | http://www.w3.org/2000/01/rdf-schema#comment | "Mutations in the Park2 gene, encoding the E3 ubiquitin-ligase parkin, are responsible for a familial form of Parkinson's disease (PD). Parkin-mediated ubiquitination is critical for the efficient elimination of depolarized dysfunctional mitochondria by autophagy (mitophagy). As damaged mitochondria are a major source of toxic reactive oxygen species within the cell, this pathway is believed to be highly relevant to the pathogenesis of PD. Little is known about how parkin-mediated ubiquitination is regulated during mitophagy or about the nature of the ubiquitin conjugates involved. We report here that USP8/UBPY, a deubiquitinating enzyme not previously implicated in mitochondrial quality control, is critical for parkin-mediated mitophagy. USP8 preferentially removes non-canonical K6-linked ubiquitin chains from parkin, a process required for the efficient recruitment of parkin to depolarized mitochondria and for their subsequent elimination by mitophagy. This work uncovers a novel role for USP8-mediated deubiquitination of K6-linked ubiquitin conjugates from parkin in mitochondrial quality control."xsd:string |
| http://purl.uniprot.org/citations/25216678 | http://purl.org/dc/terms/identifier | "doi:10.15252/embj.201489729"xsd:string |
| http://purl.uniprot.org/citations/25216678 | http://purl.uniprot.org/core/author | "Gros P."xsd:string |
| http://purl.uniprot.org/citations/25216678 | http://purl.uniprot.org/core/author | "Aguileta M.A."xsd:string |
| http://purl.uniprot.org/citations/25216678 | http://purl.uniprot.org/core/author | "Fon E.A."xsd:string |
| http://purl.uniprot.org/citations/25216678 | http://purl.uniprot.org/core/author | "Coulombe B."xsd:string |
| http://purl.uniprot.org/citations/25216678 | http://purl.uniprot.org/core/author | "Faubert D."xsd:string |
| http://purl.uniprot.org/citations/25216678 | http://purl.uniprot.org/core/author | "Shaler T.A."xsd:string |
| http://purl.uniprot.org/citations/25216678 | http://purl.uniprot.org/core/author | "McLelland G.L."xsd:string |
| http://purl.uniprot.org/citations/25216678 | http://purl.uniprot.org/core/author | "Tang M.Y."xsd:string |
| http://purl.uniprot.org/citations/25216678 | http://purl.uniprot.org/core/author | "Durcan T.M."xsd:string |
| http://purl.uniprot.org/citations/25216678 | http://purl.uniprot.org/core/author | "Dashti E.A."xsd:string |
| http://purl.uniprot.org/citations/25216678 | http://purl.uniprot.org/core/author | "Perusse J.R."xsd:string |
| http://purl.uniprot.org/citations/25216678 | http://purl.uniprot.org/core/date | "2014"xsd:gYear |
| http://purl.uniprot.org/citations/25216678 | http://purl.uniprot.org/core/name | "EMBO J"xsd:string |
| http://purl.uniprot.org/citations/25216678 | http://purl.uniprot.org/core/pages | "2473-2491"xsd:string |
| http://purl.uniprot.org/citations/25216678 | http://purl.uniprot.org/core/title | "USP8 regulates mitophagy by removing K6-linked ubiquitin conjugates from parkin."xsd:string |
| http://purl.uniprot.org/citations/25216678 | http://purl.uniprot.org/core/volume | "33"xsd:string |
| http://purl.uniprot.org/citations/25216678 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/25216678 |
| http://purl.uniprot.org/citations/25216678 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/25216678 |
| http://purl.uniprot.org/uniprot/#_A0A087WQJ2-mappedCitation-25216678 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25216678 |
| http://purl.uniprot.org/uniprot/#_D3JZW5-mappedCitation-25216678 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25216678 |
| http://purl.uniprot.org/uniprot/#_D3K2X1-mappedCitation-25216678 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25216678 |
| http://purl.uniprot.org/uniprot/#_D3K2X2-mappedCitation-25216678 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25216678 |