| http://purl.uniprot.org/citations/25224220 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/25224220 | http://www.w3.org/2000/01/rdf-schema#comment | "Epithelial sheet movement is an essential morphogenetic process during mouse embryonic eyelid closure in which Mitogen-Activated Protein 3 Kinase 1 (MAP3K1) and c-Jun play a critical role. Here we show that MAP3K1 associates with the cytoskeleton, activates Jun N-terminal kinase (JNK) and actin polymerization, and promotes the eyelid inferior epithelial cell elongation and epithelium protrusion. Following epithelium protrusion, c-Jun begins to express and acts to promote ERK phosphorylation and migration of the protruding epithelial cells. Homozygous deletion of either gene causes defective eyelid closure, but non-allelic non-complementation does not occur between Map3k1 and c-Jun and the double heterozygotes have normal eyelid closure. Results from this study suggest that MAP3K1 and c-Jun signal through distinct temporal-spatial pathways and that productive epithelium movement for eyelid closure requires the consecutive action of MAP3K1-dependent cytoskeleton reorganization followed by c-Jun-mediated migration."xsd:string |
| http://purl.uniprot.org/citations/25224220 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.ydbio.2014.09.001"xsd:string |
| http://purl.uniprot.org/citations/25224220 | http://purl.uniprot.org/core/author | "Tang X."xsd:string |
| http://purl.uniprot.org/citations/25224220 | http://purl.uniprot.org/core/author | "Wang J."xsd:string |
| http://purl.uniprot.org/citations/25224220 | http://purl.uniprot.org/core/author | "Zhang J."xsd:string |
| http://purl.uniprot.org/citations/25224220 | http://purl.uniprot.org/core/author | "Xia Y."xsd:string |
| http://purl.uniprot.org/citations/25224220 | http://purl.uniprot.org/core/author | "Meng Q."xsd:string |
| http://purl.uniprot.org/citations/25224220 | http://purl.uniprot.org/core/author | "Kao W."xsd:string |
| http://purl.uniprot.org/citations/25224220 | http://purl.uniprot.org/core/author | "Mongan M."xsd:string |
| http://purl.uniprot.org/citations/25224220 | http://purl.uniprot.org/core/date | "2014"xsd:gYear |
| http://purl.uniprot.org/citations/25224220 | http://purl.uniprot.org/core/name | "Dev Biol"xsd:string |
| http://purl.uniprot.org/citations/25224220 | http://purl.uniprot.org/core/pages | "29-37"xsd:string |
| http://purl.uniprot.org/citations/25224220 | http://purl.uniprot.org/core/title | "Epithelial sheet movement requires the cooperation of c-Jun and MAP3K1."xsd:string |
| http://purl.uniprot.org/citations/25224220 | http://purl.uniprot.org/core/volume | "395"xsd:string |
| http://purl.uniprot.org/citations/25224220 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/25224220 |
| http://purl.uniprot.org/citations/25224220 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/25224220 |
| http://purl.uniprot.org/uniprot/P05627#attribution-3999D5E308E115970CED19461A6A733B | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/25224220 |
| http://purl.uniprot.org/uniprot/P53349#attribution-3999D5E308E115970CED19461A6A733B | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/25224220 |
| http://purl.uniprot.org/uniprot/P53349#attribution-60EF4F9BB5F5E53D6468288BBE58041F | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/25224220 |
| http://purl.uniprot.org/uniprot/#_D3Z7S6-mappedCitation-25224220 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25224220 |
| http://purl.uniprot.org/uniprot/#_D3YVX9-mappedCitation-25224220 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25224220 |
| http://purl.uniprot.org/uniprot/#_D3Z5Q1-mappedCitation-25224220 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25224220 |
| http://purl.uniprot.org/uniprot/#_E9Q6A9-mappedCitation-25224220 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25224220 |
| http://purl.uniprot.org/uniprot/#_P63085-mappedCitation-25224220 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25224220 |