| http://purl.uniprot.org/citations/25237846 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/25237846 | http://www.w3.org/2000/01/rdf-schema#comment | "The purpose of the present study was to investigate the effect of interferon (IFN)-γ on the transcriptomic profile of differentiating mouse C2C12 myogenic cells. Global gene expression was evaluated using whole mouse genome oligonucleotide microarrays, and the results were validated through real-time PCR. IFN-γ (1 ng/mL) increased myoblast proliferation but decreased cell respiration and myosin heavy chain content and slightly decreased the fusion index in differentiating C2C12 cell cultures. The genes upregulated through IFN-γ were involved in cell cycle; regulation of cell proliferation; programmed cell death; chemotaxis; and cytokine, growth factor, and peptidase activity, whereas the genes downregulated through IFN-γ primarily contributed to the regulation of transcription, cell-cell signaling, nitrogen compound biosynthesis, ser/thr protein kinase signaling, and regulation of the Wnt pathway. In conclusion, IFN-γ affects the expression of numerous genes associated with the regulation of several processes in myogenesis. The effects of IFN-γ on cellular transcription include (1) alteration of cytokine/growth factor expression, promoting cell proliferation and migration but inhibiting differentiation, (2) impairment of pro-myogenic transcription, (3) disruption of cell adhesion and sarcolemma/cytoskeleton organization, and (4) increased peptidase activity leading to enhanced proteolysis and apoptosis."xsd:string |
| http://purl.uniprot.org/citations/25237846 | http://purl.org/dc/terms/identifier | "doi:10.1089/jir.2014.0018"xsd:string |
| http://purl.uniprot.org/citations/25237846 | http://purl.uniprot.org/core/author | "Blaszczyk M."xsd:string |
| http://purl.uniprot.org/citations/25237846 | http://purl.uniprot.org/core/author | "Kozlowski M."xsd:string |
| http://purl.uniprot.org/citations/25237846 | http://purl.uniprot.org/core/author | "Majewska A."xsd:string |
| http://purl.uniprot.org/citations/25237846 | http://purl.uniprot.org/core/author | "Milewska M."xsd:string |
| http://purl.uniprot.org/citations/25237846 | http://purl.uniprot.org/core/author | "Grzelkowska-Kowalczyk K."xsd:string |
| http://purl.uniprot.org/citations/25237846 | http://purl.uniprot.org/core/author | "Wicik Z."xsd:string |
| http://purl.uniprot.org/citations/25237846 | http://purl.uniprot.org/core/author | "Grabiec K."xsd:string |
| http://purl.uniprot.org/citations/25237846 | http://purl.uniprot.org/core/author | "Tokarska J."xsd:string |
| http://purl.uniprot.org/citations/25237846 | http://purl.uniprot.org/core/date | "2015"xsd:gYear |
| http://purl.uniprot.org/citations/25237846 | http://purl.uniprot.org/core/name | "J Interferon Cytokine Res"xsd:string |
| http://purl.uniprot.org/citations/25237846 | http://purl.uniprot.org/core/pages | "89-99"xsd:string |
| http://purl.uniprot.org/citations/25237846 | http://purl.uniprot.org/core/title | "Transcriptional regulation of important cellular processes in skeletal myogenesis through interferon-gamma."xsd:string |
| http://purl.uniprot.org/citations/25237846 | http://purl.uniprot.org/core/volume | "35"xsd:string |
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