| http://purl.uniprot.org/citations/25238095 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/25238095 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/25238095 | http://www.w3.org/2000/01/rdf-schema#comment | "SLC15A4 is a lysosome-resident, proton-coupled amino-acid transporter that moves histidine and oligopeptides from inside the lysosome to the cytosol of eukaryotic cells. SLC15A4 is required for Toll-like receptor 7 (TLR7)- and TLR9-mediated type I interferon (IFN-I) productions in plasmacytoid dendritic cells (pDCs) and is involved in the pathogenesis of certain diseases including lupus-like autoimmunity. How SLC15A4 contributes to diseases is largely unknown. Here we have shown that B cell SLC15A4 was crucial for TLR7-triggered IFN-I and autoantibody productions in a mouse lupus model. SLC15A4 loss disturbed the endolysosomal pH regulation and probably the v-ATPase integrity, and these changes were associated with disruption of the mTOR pathway, leading to failure of the IFN regulatory factor 7 (IRF7)-IFN-I regulatory circuit. Importantly, SLC15A4's transporter activity was necessary for the TLR-triggered cytokine production. Our findings revealed that SLC15A4-mediated optimization of the endolysosomal state is integral to a TLR7-triggered, mTOR-dependent IRF7-IFN-I circuit that leads to autoantibody production."xsd:string |
| http://purl.uniprot.org/citations/25238095 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.immuni.2014.08.011"xsd:string |
| http://purl.uniprot.org/citations/25238095 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.immuni.2014.08.011"xsd:string |
| http://purl.uniprot.org/citations/25238095 | http://purl.uniprot.org/core/author | "Kobayashi T."xsd:string |
| http://purl.uniprot.org/citations/25238095 | http://purl.uniprot.org/core/author | "Kobayashi T."xsd:string |
| http://purl.uniprot.org/citations/25238095 | http://purl.uniprot.org/core/author | "Kato N."xsd:string |
| http://purl.uniprot.org/citations/25238095 | http://purl.uniprot.org/core/author | "Kato N."xsd:string |
| http://purl.uniprot.org/citations/25238095 | http://purl.uniprot.org/core/author | "Okamura T."xsd:string |
| http://purl.uniprot.org/citations/25238095 | http://purl.uniprot.org/core/author | "Okamura T."xsd:string |
| http://purl.uniprot.org/citations/25238095 | http://purl.uniprot.org/core/author | "Shimizu Y."xsd:string |
| http://purl.uniprot.org/citations/25238095 | http://purl.uniprot.org/core/author | "Shimizu Y."xsd:string |
| http://purl.uniprot.org/citations/25238095 | http://purl.uniprot.org/core/author | "Yokoyama S."xsd:string |
| http://purl.uniprot.org/citations/25238095 | http://purl.uniprot.org/core/author | "Yokoyama S."xsd:string |
| http://purl.uniprot.org/citations/25238095 | http://purl.uniprot.org/core/author | "Hosaka T."xsd:string |
| http://purl.uniprot.org/citations/25238095 | http://purl.uniprot.org/core/author | "Hosaka T."xsd:string |
| http://purl.uniprot.org/citations/25238095 | http://purl.uniprot.org/core/author | "Goto M."xsd:string |
| http://purl.uniprot.org/citations/25238095 | http://purl.uniprot.org/core/author | "Goto M."xsd:string |
| http://purl.uniprot.org/citations/25238095 | http://purl.uniprot.org/core/author | "Sugiura Y."xsd:string |
| http://purl.uniprot.org/citations/25238095 | http://purl.uniprot.org/core/author | "Sugiura Y."xsd:string |
| http://purl.uniprot.org/citations/25238095 | http://purl.uniprot.org/core/author | "Suematsu M."xsd:string |
| http://purl.uniprot.org/citations/25238095 | http://purl.uniprot.org/core/author | "Suematsu M."xsd:string |
| http://purl.uniprot.org/citations/25238095 | http://purl.uniprot.org/core/author | "Toyama-Sorimachi N."xsd:string |
| http://purl.uniprot.org/citations/25238095 | http://purl.uniprot.org/core/author | "Toyama-Sorimachi N."xsd:string |