| http://purl.uniprot.org/citations/25239187 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/25239187 | http://www.w3.org/2000/01/rdf-schema#comment | "The production of type I interferon must be tightly regulated, and the aberrant production of this protein is harmful or even fatal to the host. The transcription factor IRF3 phosphorylation is a central regulator of type I interferon meditated antiviral response. Protein phosphatase-1 (PP1) has been reported to be important in many cell functions, including development, differentiation, and tumorigenesis. However, the roles of PP1 in Toll-like receptor (TLR)- or retinoic acid-inducible gene I like receptor (RLR)-triggered IRF-3 activation remain unclear. Here, we show that the activity of PP1 is downregulated in macrophages upon stimulation with TLR or RLR ligands, including lipopolysaccharide, and poly(I:C), or vesicular stomatitis virus (VSV), respectively. The overexpression of PP1 selectively inhibits TLR- and VSV-induced interferon regulatory factor 3 (IRF3) activation but has no substantial effect on TANK-binding kinase 1 (TBK1),ΚB kinase ε (IKKε) activation. Conversely, RNA interference of PP1 significantly promotes IRF3 activation. Consistently, The overexpression of PP1 inhibits TLR- and VSV-triggered IFN-β production while PP1 knockdown significantly increases the production of IFN-β in macrophages. We further demonstrate that PP1 directly interacts with IRF3 and dephosphorylates IRF3 at Ser385 and Ser396, resulting in the suppression of TLR- and RLR-triggered IFN-β production. Thus, PP1 functions as a negative feedback regulator of TLR- and RLR-triggered antiviral immune responses by acting as an IRF3 phosphatase."xsd:string |
| http://purl.uniprot.org/citations/25239187 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.cellsig.2014.09.007"xsd:string |
| http://purl.uniprot.org/citations/25239187 | http://purl.uniprot.org/core/author | "Gu M."xsd:string |
| http://purl.uniprot.org/citations/25239187 | http://purl.uniprot.org/core/author | "Huang H."xsd:string |
| http://purl.uniprot.org/citations/25239187 | http://purl.uniprot.org/core/author | "Lai R."xsd:string |
| http://purl.uniprot.org/citations/25239187 | http://purl.uniprot.org/core/author | "Liu Z."xsd:string |
| http://purl.uniprot.org/citations/25239187 | http://purl.uniprot.org/core/author | "Zhang T."xsd:string |
| http://purl.uniprot.org/citations/25239187 | http://purl.uniprot.org/core/author | "Wang X."xsd:string |
| http://purl.uniprot.org/citations/25239187 | http://purl.uniprot.org/core/author | "Xia D."xsd:string |
| http://purl.uniprot.org/citations/25239187 | http://purl.uniprot.org/core/author | "lin W."xsd:string |
| http://purl.uniprot.org/citations/25239187 | http://purl.uniprot.org/core/date | "2014"xsd:gYear |
| http://purl.uniprot.org/citations/25239187 | http://purl.uniprot.org/core/name | "Cell Signal"xsd:string |
| http://purl.uniprot.org/citations/25239187 | http://purl.uniprot.org/core/pages | "2930-2939"xsd:string |
| http://purl.uniprot.org/citations/25239187 | http://purl.uniprot.org/core/title | "Protein phosphatase PP1 negatively regulates the Toll-like receptor- and RIG-I-like receptor-triggered production of type I interferon by inhibiting IRF3 phosphorylation at serines 396 and 385 in macrophage."xsd:string |
| http://purl.uniprot.org/citations/25239187 | http://purl.uniprot.org/core/volume | "26"xsd:string |
| http://purl.uniprot.org/citations/25239187 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/25239187 |
| http://purl.uniprot.org/citations/25239187 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/25239187 |
| http://purl.uniprot.org/uniprot/#_P63087-mappedCitation-25239187 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25239187 |
| http://purl.uniprot.org/uniprot/#_P70671-mappedCitation-25239187 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25239187 |
| http://purl.uniprot.org/uniprot/#_Q0VE17-mappedCitation-25239187 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25239187 |
| http://purl.uniprot.org/uniprot/#_C0IXK2-mappedCitation-25239187 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25239187 |
| http://purl.uniprot.org/uniprot/#_P01575-mappedCitation-25239187 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25239187 |
| http://purl.uniprot.org/uniprot/#_O54726-mappedCitation-25239187 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25239187 |
| http://purl.uniprot.org/uniprot/#_Q3U9K6-mappedCitation-25239187 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25239187 |