| http://purl.uniprot.org/citations/25240383 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/25240383 | http://www.w3.org/2000/01/rdf-schema#comment | "It remains largely unclear how antigen-presenting cells (APCs) encounter effector or memory T cells efficiently in the periphery. Here we used a mouse contact hypersensitivity (CHS) model to show that upon epicutaneous antigen challenge, dendritic cells (DCs) formed clusters with effector T cells in dermal perivascular areas to promote in situ proliferation and activation of skin T cells in a manner dependent on antigen and the integrin LFA-1. We found that DCs accumulated in perivascular areas and that DC clustering was abrogated by depletion of macrophages. Treatment with interleukin 1α (IL-1α) induced production of the chemokine CXCL2 by dermal macrophages, and DC clustering was suppressed by blockade of either the receptor for IL-1 (IL-1R) or the receptor for CXCL2 (CXCR2). Our findings suggest that the dermal leukocyte cluster is an essential structure for elicitating acquired cutaneous immunity."xsd:string |
| http://purl.uniprot.org/citations/25240383 | http://purl.org/dc/terms/identifier | "doi:10.1038/ni.2992"xsd:string |
| http://purl.uniprot.org/citations/25240383 | http://purl.uniprot.org/core/author | "Honda T."xsd:string |
| http://purl.uniprot.org/citations/25240383 | http://purl.uniprot.org/core/author | "Hashimoto T."xsd:string |
| http://purl.uniprot.org/citations/25240383 | http://purl.uniprot.org/core/author | "Kubo M."xsd:string |
| http://purl.uniprot.org/citations/25240383 | http://purl.uniprot.org/core/author | "Okada T."xsd:string |
| http://purl.uniprot.org/citations/25240383 | http://purl.uniprot.org/core/author | "Ono S."xsd:string |
| http://purl.uniprot.org/citations/25240383 | http://purl.uniprot.org/core/author | "Tsutsui H."xsd:string |
| http://purl.uniprot.org/citations/25240383 | http://purl.uniprot.org/core/author | "Sugimoto Y."xsd:string |
| http://purl.uniprot.org/citations/25240383 | http://purl.uniprot.org/core/author | "Iwakura Y."xsd:string |
| http://purl.uniprot.org/citations/25240383 | http://purl.uniprot.org/core/author | "Nakajima S."xsd:string |
| http://purl.uniprot.org/citations/25240383 | http://purl.uniprot.org/core/author | "Tsuchiya S."xsd:string |
| http://purl.uniprot.org/citations/25240383 | http://purl.uniprot.org/core/author | "Miyachi Y."xsd:string |
| http://purl.uniprot.org/citations/25240383 | http://purl.uniprot.org/core/author | "Ishii K.J."xsd:string |
| http://purl.uniprot.org/citations/25240383 | http://purl.uniprot.org/core/author | "Yagita H."xsd:string |
| http://purl.uniprot.org/citations/25240383 | http://purl.uniprot.org/core/author | "Guttman-Yassky E."xsd:string |
| http://purl.uniprot.org/citations/25240383 | http://purl.uniprot.org/core/author | "Kabashima K."xsd:string |
| http://purl.uniprot.org/citations/25240383 | http://purl.uniprot.org/core/author | "Nakamizo S."xsd:string |
| http://purl.uniprot.org/citations/25240383 | http://purl.uniprot.org/core/author | "Otsuka A."xsd:string |
| http://purl.uniprot.org/citations/25240383 | http://purl.uniprot.org/core/author | "Fuentes J."xsd:string |
| http://purl.uniprot.org/citations/25240383 | http://purl.uniprot.org/core/author | "Kitoh A."xsd:string |
| http://purl.uniprot.org/citations/25240383 | http://purl.uniprot.org/core/author | "Egawa G."xsd:string |
| http://purl.uniprot.org/citations/25240383 | http://purl.uniprot.org/core/author | "Natsuaki Y."xsd:string |
| http://purl.uniprot.org/citations/25240383 | http://purl.uniprot.org/core/author | "Hanakawa S."xsd:string |