| http://purl.uniprot.org/citations/25242226 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/25242226 | http://www.w3.org/2000/01/rdf-schema#comment | "Adipose tissue macrophage (ATM)-driven inflammation plays a key role in insulin resistance; however, factors activating ATMs are poorly understood. Using a proteomics approach, we show that markers of classical activation are absent on ATMs from obese humans but are readily detectable on airway macrophages of patients with cystic fibrosis, a disease associated with chronic bacterial infection. Moreover, treating macrophages with glucose, insulin, and palmitate-conditions characteristic of the metabolic syndrome-produces a "metabolically activated" phenotype distinct from classical activation. Markers of metabolic activation are expressed by proinflammatory ATMs in obese humans/mice and are positively correlated with adiposity. Metabolic activation is driven by independent proinflammatory and anti-inflammatory pathways, which regulate balance between cytokine production and lipid metabolism. We identify PPARγ and p62/SQSTM1 as two key proteins that promote lipid metabolism and limit inflammation in metabolically activated macrophages. Collectively, our data provide important mechanistic insights into pathways that drive the metabolic-disease-specific phenotype of macrophages."xsd:string |
| http://purl.uniprot.org/citations/25242226 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.cmet.2014.08.010"xsd:string |
| http://purl.uniprot.org/citations/25242226 | http://purl.uniprot.org/core/author | "Kratz M."xsd:string |
| http://purl.uniprot.org/citations/25242226 | http://purl.uniprot.org/core/author | "Hwang S."xsd:string |
| http://purl.uniprot.org/citations/25242226 | http://purl.uniprot.org/core/author | "Singh P.K."xsd:string |
| http://purl.uniprot.org/citations/25242226 | http://purl.uniprot.org/core/author | "Becker L."xsd:string |
| http://purl.uniprot.org/citations/25242226 | http://purl.uniprot.org/core/author | "Hisert K.B."xsd:string |
| http://purl.uniprot.org/citations/25242226 | http://purl.uniprot.org/core/author | "Gozal D."xsd:string |
| http://purl.uniprot.org/citations/25242226 | http://purl.uniprot.org/core/author | "Larson I."xsd:string |
| http://purl.uniprot.org/citations/25242226 | http://purl.uniprot.org/core/author | "Mutskov V."xsd:string |
| http://purl.uniprot.org/citations/25242226 | http://purl.uniprot.org/core/author | "Crouthamel M."xsd:string |
| http://purl.uniprot.org/citations/25242226 | http://purl.uniprot.org/core/author | "Peris E."xsd:string |
| http://purl.uniprot.org/citations/25242226 | http://purl.uniprot.org/core/author | "Billing P.S."xsd:string |
| http://purl.uniprot.org/citations/25242226 | http://purl.uniprot.org/core/author | "Coats B.R."xsd:string |
| http://purl.uniprot.org/citations/25242226 | http://purl.uniprot.org/core/author | "Hagman D."xsd:string |
| http://purl.uniprot.org/citations/25242226 | http://purl.uniprot.org/core/author | "Kuzma J.N."xsd:string |
| http://purl.uniprot.org/citations/25242226 | http://purl.uniprot.org/core/author | "Landerholm R.W."xsd:string |
| http://purl.uniprot.org/citations/25242226 | http://purl.uniprot.org/core/author | "Schoenfelt K.Q."xsd:string |
| http://purl.uniprot.org/citations/25242226 | http://purl.uniprot.org/core/date | "2014"xsd:gYear |
| http://purl.uniprot.org/citations/25242226 | http://purl.uniprot.org/core/name | "Cell Metab"xsd:string |
| http://purl.uniprot.org/citations/25242226 | http://purl.uniprot.org/core/pages | "614-625"xsd:string |
| http://purl.uniprot.org/citations/25242226 | http://purl.uniprot.org/core/title | "Metabolic dysfunction drives a mechanistically distinct proinflammatory phenotype in adipose tissue macrophages."xsd:string |
| http://purl.uniprot.org/citations/25242226 | http://purl.uniprot.org/core/volume | "20"xsd:string |
| http://purl.uniprot.org/citations/25242226 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/25242226 |