| http://purl.uniprot.org/citations/25243920 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/25243920 | http://www.w3.org/2000/01/rdf-schema#comment | "Human herpesvirus 6B (HHV-6B) is a ubiquitous pathogen with frequent reactivation observed in immunocompromised patients such as BM transplant (BMT) recipients. Adoptive immunotherapy is a promising therapeutic avenue for the treatment of opportunistic infections, including herpesviruses. While T-cell immunotherapy can successfully control CMV and EBV reactivations in BMT recipients, such therapy is not available for HHV-6 infections, in part due to a lack of identified protective CD8(+) T-cell epitopes. Our goal was to identify CD8(+) T-cell viral epitopes derived from the HHV-6B immediate-early protein I and presented by common human leukocyte Ag (HLA) class I alleles including HLA-A*02, HLA-A*03, and HLA-B*07. These epitopes were functionally tested for their ability to induce CD8(+) T-cell expansion and kill HHV-6-infected autologous cells. Cross-reactivity of specific HHV-6B-expanded T cells against HHV-6A-infected cells was also confirmed for a conserved epitope presented by HLA-A*02 molecule. Our findings will help push forward the field of adoptive immunotherapy for the treatment and/or the prevention of HHV-6 reactivation in BMT recipients."xsd:string |
| http://purl.uniprot.org/citations/25243920 | http://purl.org/dc/terms/identifier | "doi:10.1002/eji.201444931"xsd:string |
| http://purl.uniprot.org/citations/25243920 | http://purl.uniprot.org/core/author | "Flamand L."xsd:string |
| http://purl.uniprot.org/citations/25243920 | http://purl.uniprot.org/core/author | "Gravel A."xsd:string |
| http://purl.uniprot.org/citations/25243920 | http://purl.uniprot.org/core/author | "Iampietro M."xsd:string |
| http://purl.uniprot.org/citations/25243920 | http://purl.uniprot.org/core/author | "Hasan A."xsd:string |
| http://purl.uniprot.org/citations/25243920 | http://purl.uniprot.org/core/author | "Rousseau M."xsd:string |
| http://purl.uniprot.org/citations/25243920 | http://purl.uniprot.org/core/author | "O'Reilly R.J."xsd:string |
| http://purl.uniprot.org/citations/25243920 | http://purl.uniprot.org/core/author | "Morissette G."xsd:string |
| http://purl.uniprot.org/citations/25243920 | http://purl.uniprot.org/core/author | "Dubuc I."xsd:string |
| http://purl.uniprot.org/citations/25243920 | http://purl.uniprot.org/core/date | "2014"xsd:gYear |
| http://purl.uniprot.org/citations/25243920 | http://purl.uniprot.org/core/name | "Eur J Immunol"xsd:string |
| http://purl.uniprot.org/citations/25243920 | http://purl.uniprot.org/core/pages | "3573-3584"xsd:string |
| http://purl.uniprot.org/citations/25243920 | http://purl.uniprot.org/core/title | "Human herpesvirus 6B immediate-early I protein contains functional HLA-A*02, HLA-A*03, and HLA-B*07 class I restricted CD8(+) T-cell epitopes."xsd:string |
| http://purl.uniprot.org/citations/25243920 | http://purl.uniprot.org/core/volume | "44"xsd:string |
| http://purl.uniprot.org/citations/25243920 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/25243920 |
| http://purl.uniprot.org/citations/25243920 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/25243920 |
| http://purl.uniprot.org/uniprot/#_A0A0A7C543-mappedCitation-25243920 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25243920 |
| http://purl.uniprot.org/uniprot/#_A0A0A7C548-mappedCitation-25243920 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25243920 |
| http://purl.uniprot.org/uniprot/#_A0A0A7C551-mappedCitation-25243920 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25243920 |
| http://purl.uniprot.org/uniprot/#_A0A0A7C552-mappedCitation-25243920 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25243920 |
| http://purl.uniprot.org/uniprot/#_A0A0E3DC98-mappedCitation-25243920 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25243920 |
| http://purl.uniprot.org/uniprot/#_A0A0E3DCA0-mappedCitation-25243920 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25243920 |
| http://purl.uniprot.org/uniprot/#_A0A0E3DCA1-mappedCitation-25243920 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25243920 |