| http://purl.uniprot.org/citations/25247702 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/25247702 | http://www.w3.org/2000/01/rdf-schema#comment | "Translational readthrough gives rise to low abundance proteins with C-terminal extensions beyond the stop codon. To identify functional translational readthrough, we estimated the readthrough propensity (RTP) of all stop codon contexts of the human genome by a new regression model in silico, identified a nucleotide consensus motif for high RTP by using this model, and analyzed all readthrough extensions in silico with a new predictor for peroxisomal targeting signal type 1 (PTS1). Lactate dehydrogenase B (LDHB) showed the highest combined RTP and PTS1 probability. Experimentally we show that at least 1.6% of the total cellular LDHB is targeted to the peroxisome by a conserved hidden PTS1. The readthrough-extended lactate dehydrogenase subunit LDHBx can also co-import LDHA, the other LDH subunit, into peroxisomes. Peroxisomal LDH is conserved in mammals and likely contributes to redox equivalent regeneration in peroxisomes."xsd:string |
| http://purl.uniprot.org/citations/25247702 | http://purl.org/dc/terms/identifier | "doi:10.7554/elife.03640"xsd:string |
| http://purl.uniprot.org/citations/25247702 | http://purl.uniprot.org/core/author | "George R."xsd:string |
| http://purl.uniprot.org/citations/25247702 | http://purl.uniprot.org/core/author | "Gartner J."xsd:string |
| http://purl.uniprot.org/citations/25247702 | http://purl.uniprot.org/core/author | "Thoms S."xsd:string |
| http://purl.uniprot.org/citations/25247702 | http://purl.uniprot.org/core/author | "Lingner T."xsd:string |
| http://purl.uniprot.org/citations/25247702 | http://purl.uniprot.org/core/author | "Dickel C."xsd:string |
| http://purl.uniprot.org/citations/25247702 | http://purl.uniprot.org/core/author | "Hofhuis J."xsd:string |
| http://purl.uniprot.org/citations/25247702 | http://purl.uniprot.org/core/author | "Schueren F."xsd:string |
| http://purl.uniprot.org/citations/25247702 | http://purl.uniprot.org/core/date | "2014"xsd:gYear |
| http://purl.uniprot.org/citations/25247702 | http://purl.uniprot.org/core/name | "Elife"xsd:string |
| http://purl.uniprot.org/citations/25247702 | http://purl.uniprot.org/core/pages | "e03640"xsd:string |
| http://purl.uniprot.org/citations/25247702 | http://purl.uniprot.org/core/title | "Peroxisomal lactate dehydrogenase is generated by translational readthrough in mammals."xsd:string |
| http://purl.uniprot.org/citations/25247702 | http://purl.uniprot.org/core/volume | "3"xsd:string |
| http://purl.uniprot.org/citations/25247702 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/25247702 |
| http://purl.uniprot.org/citations/25247702 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/25247702 |
| http://purl.uniprot.org/uniprot/#_A0A5F9ZHM4-mappedCitation-25247702 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25247702 |
| http://purl.uniprot.org/uniprot/#_A6IMU4-mappedCitation-25247702 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25247702 |
| http://purl.uniprot.org/uniprot/#_A6IMU6-mappedCitation-25247702 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25247702 |
| http://purl.uniprot.org/uniprot/#_P42123-mappedCitation-25247702 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25247702 |
| http://purl.uniprot.org/uniprot/#_P07195-mappedCitation-25247702 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25247702 |
| http://purl.uniprot.org/uniprot/#_Q59G78-mappedCitation-25247702 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25247702 |
| http://purl.uniprot.org/uniprot/#_Q5U077-mappedCitation-25247702 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25247702 |
| http://purl.uniprot.org/uniprot/P42123 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/25247702 |