| http://purl.uniprot.org/citations/25249460 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/25249460 | http://www.w3.org/2000/01/rdf-schema#comment | "The molecular signals driving tendon development are not fully identified. We have undertaken a transcriptome analysis of mouse limb tendon cells that were isolated at different stages of development based on scleraxis (Scx) expression. Microarray comparisons allowed us to establish a list of genes regulated in tendon cells during mouse limb development. Bioinformatics analysis of the tendon transcriptome showed that the two most strongly modified signalling pathways were TGF-β and MAPK. TGF-β/SMAD2/3 gain- and loss-of-function experiments in mouse limb explants and mesenchymal stem cells showed that TGF-β signalling was sufficient and required via SMAD2/3 to drive mouse mesodermal stem cells towards the tendon lineage ex vivo and in vitro. TGF-β was also sufficient for tendon gene expression in late limb explants during tendon differentiation. FGF does not have a tenogenic effect and the inhibition of the ERK MAPK signalling pathway was sufficient to activate Scx in mouse limb mesodermal progenitors and mesenchymal stem cells."xsd:string |
| http://purl.uniprot.org/citations/25249460 | http://purl.org/dc/terms/identifier | "doi:10.1242/dev.108654"xsd:string |
| http://purl.uniprot.org/citations/25249460 | http://purl.uniprot.org/core/author | "Ruggiero F."xsd:string |
| http://purl.uniprot.org/citations/25249460 | http://purl.uniprot.org/core/author | "Ruggiu M."xsd:string |
| http://purl.uniprot.org/citations/25249460 | http://purl.uniprot.org/core/author | "Duprez D."xsd:string |
| http://purl.uniprot.org/citations/25249460 | http://purl.uniprot.org/core/author | "Bonod-Bidaud C."xsd:string |
| http://purl.uniprot.org/citations/25249460 | http://purl.uniprot.org/core/author | "Durand C."xsd:string |
| http://purl.uniprot.org/citations/25249460 | http://purl.uniprot.org/core/author | "Havis E."xsd:string |
| http://purl.uniprot.org/citations/25249460 | http://purl.uniprot.org/core/author | "Schweitzer R."xsd:string |
| http://purl.uniprot.org/citations/25249460 | http://purl.uniprot.org/core/author | "Guerquin M.J."xsd:string |
| http://purl.uniprot.org/citations/25249460 | http://purl.uniprot.org/core/author | "Bonnin M.A."xsd:string |
| http://purl.uniprot.org/citations/25249460 | http://purl.uniprot.org/core/author | "Nazaret N."xsd:string |
| http://purl.uniprot.org/citations/25249460 | http://purl.uniprot.org/core/author | "Weibel J."xsd:string |
| http://purl.uniprot.org/citations/25249460 | http://purl.uniprot.org/core/author | "Olivera-Martinez I."xsd:string |
| http://purl.uniprot.org/citations/25249460 | http://purl.uniprot.org/core/date | "2014"xsd:gYear |
| http://purl.uniprot.org/citations/25249460 | http://purl.uniprot.org/core/name | "Development"xsd:string |
| http://purl.uniprot.org/citations/25249460 | http://purl.uniprot.org/core/pages | "3683-3696"xsd:string |
| http://purl.uniprot.org/citations/25249460 | http://purl.uniprot.org/core/title | "Transcriptomic analysis of mouse limb tendon cells during development."xsd:string |
| http://purl.uniprot.org/citations/25249460 | http://purl.uniprot.org/core/volume | "141"xsd:string |
| http://purl.uniprot.org/citations/25249460 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/25249460 |
| http://purl.uniprot.org/citations/25249460 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/25249460 |
| http://purl.uniprot.org/uniprot/#_A0A0A6YXU9-mappedCitation-25249460 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25249460 |
| http://purl.uniprot.org/uniprot/#_A0A0J9YU80-mappedCitation-25249460 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25249460 |
| http://purl.uniprot.org/uniprot/#_A0A0J9YV92-mappedCitation-25249460 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25249460 |