| http://purl.uniprot.org/citations/25250214 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/25250214 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/25250214 | http://www.w3.org/2000/01/rdf-schema#comment | "Interleukin-18 (IL-18) is a pro-inflammatory cytokine which stimulates activation of the nuclear factor kappa beta (NF-κB) pathway via interaction with the IL-18 receptor. The receptor itself is formed from a dimer of two subunits, with the ligand-binding IL-18Rα subunit being encoded by the IL18R1 gene. A splice variant of murine IL18r1, which has been previously described, is formed by transcription of an unspliced intron (forming a 'type II' IL18r1 transcript) and is predicted to encode a receptor with a truncated intracellular domain lacking the capacity to generate downstream signalling. In order to examine the relevance of this finding to human IL-18 function, we assessed the presence of a homologous transcript by reverse transcription-polymerase chain reaction (RT-PCR) in the human and rat as another common laboratory animal. We present evidence for type II IL18R1 transcripts in both species. While the mouse and rat transcripts are predicted to encode a truncated receptor with a novel 5 amino acid C-terminal domain, the human sequence is predicted to encode a truncated protein with a novel 22 amino acid sequence bearing resemblance to the 'Box 1' motif of the Toll/interleukin-1 receptor (TIR) domain, in a similar fashion to the inhibitory interleukin-1 receptor 2. Given that transcripts from these three species are all formed by inclusion of homologous unspliced intronic regions, an analysis of homologous introns across a wider array of 33 species with available IL18R1 gene records was performed, which suggests similar transcripts may encode truncated type II IL-18Rα subunits in other species. This splice variant may represent a conserved evolutionary mechanism for regulating IL-18 activity."xsd:string |
| http://purl.uniprot.org/citations/25250214 | http://purl.org/dc/terms/identifier | "doi:10.7717/peerj.560"xsd:string |
| http://purl.uniprot.org/citations/25250214 | http://purl.uniprot.org/core/author | "Grattan D.R."xsd:string |
| http://purl.uniprot.org/citations/25250214 | http://purl.uniprot.org/core/author | "Grattan D.R."xsd:string |
| http://purl.uniprot.org/citations/25250214 | http://purl.uniprot.org/core/author | "Booker C.S."xsd:string |
| http://purl.uniprot.org/citations/25250214 | http://purl.uniprot.org/core/author | "Booker C.S."xsd:string |
| http://purl.uniprot.org/citations/25250214 | http://purl.uniprot.org/core/date | "2014"xsd:gYear |
| http://purl.uniprot.org/citations/25250214 | http://purl.uniprot.org/core/date | "2014"xsd:gYear |
| http://purl.uniprot.org/citations/25250214 | http://purl.uniprot.org/core/name | "PeerJ"xsd:string |
| http://purl.uniprot.org/citations/25250214 | http://purl.uniprot.org/core/name | "PeerJ"xsd:string |
| http://purl.uniprot.org/citations/25250214 | http://purl.uniprot.org/core/pages | "E560"xsd:string |
| http://purl.uniprot.org/citations/25250214 | http://purl.uniprot.org/core/pages | "e560"xsd:string |
| http://purl.uniprot.org/citations/25250214 | http://purl.uniprot.org/core/title | "Identification of a truncated splice variant of IL-18 receptor alpha in the human and rat, with evidence of wider evolutionary conservation."xsd:string |
| http://purl.uniprot.org/citations/25250214 | http://purl.uniprot.org/core/title | "Identification of a truncated splice variant of IL-18 receptor alpha in the human and rat, with evidence of wider evolutionary conservation."xsd:string |
| http://purl.uniprot.org/citations/25250214 | http://purl.uniprot.org/core/volume | "2"xsd:string |
| http://purl.uniprot.org/citations/25250214 | http://purl.uniprot.org/core/volume | "2"xsd:string |
| http://purl.uniprot.org/citations/25250214 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/25250214 |
| http://purl.uniprot.org/citations/25250214 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/25250214 |
| http://purl.uniprot.org/citations/25250214 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/25250214 |
| http://purl.uniprot.org/citations/25250214 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/25250214 |
| http://purl.uniprot.org/uniprot/A0A089VIW4 | http://purl.uniprot.org/core/citation | http://purl.uniprot.org/citations/25250214 |
| http://purl.uniprot.org/uniprot/A0A089VKP9 | http://purl.uniprot.org/core/citation | http://purl.uniprot.org/citations/25250214 |
| http://purl.uniprot.org/uniprot/A0A089X9D3 | http://purl.uniprot.org/core/citation | http://purl.uniprot.org/citations/25250214 |