| http://purl.uniprot.org/citations/25250328 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/25250328 | http://www.w3.org/2000/01/rdf-schema#comment | "The purpose of this study was to investigate if PPARγ plays a role in the melanogenesis. B16/F10 cells were divided into five groups: control, melanin stimulating hormone (α-MSH), α-MSH+retinol, α-MSH+GW9662 (PPARγ antagonist), and GW9662. Cells in the control group were cultured in the Dulbecco's modified Eagle's medium (DMEM) for 48 hrs. To initiate the melanogenesis, cells in all α-MSH groups were cultured in medium containing α-MSH (10 nM) for 48 hrs. Cells were treated simultaneously with retinol (5 μM) in the α-MSH+retinol group. Instead of retinol, GW9662 (10 μM) was cocultured in the α-MSH+GW9662 group. Cells in the final group were cultured in the DMEM with GW9662. All the analyses were carried out 48 hours after treatments. The α-MSH was able to increase cell number, melanin production, and the activity of tyrosinase, the limiting enzyme in melanogenesis. These α-MSH-induced changes were prevented either by retinol or by GW9662. Further analyses of the activities of antioxidant enzymes including glutathione, catalase, and the superoxide dismutase (SOD) showed that α-MSH treatment raised the activity of SOD which was dependent on PPARγ level. According to our results, the α-MSH-induced melanogenesis was PPARγ dependent, which also modulated the expression of SOD."xsd:string |
| http://purl.uniprot.org/citations/25250328 | http://purl.org/dc/terms/identifier | "doi:10.1155/2014/695797"xsd:string |
| http://purl.uniprot.org/citations/25250328 | http://purl.uniprot.org/core/author | "Chang J.L."xsd:string |
| http://purl.uniprot.org/citations/25250328 | http://purl.uniprot.org/core/author | "Chen J.H."xsd:string |
| http://purl.uniprot.org/citations/25250328 | http://purl.uniprot.org/core/author | "Chen M.J."xsd:string |
| http://purl.uniprot.org/citations/25250328 | http://purl.uniprot.org/core/author | "Lin T.B."xsd:string |
| http://purl.uniprot.org/citations/25250328 | http://purl.uniprot.org/core/author | "Chen P.R."xsd:string |
| http://purl.uniprot.org/citations/25250328 | http://purl.uniprot.org/core/author | "Chen K.H."xsd:string |
| http://purl.uniprot.org/citations/25250328 | http://purl.uniprot.org/core/author | "Chuang Y.J."xsd:string |
| http://purl.uniprot.org/citations/25250328 | http://purl.uniprot.org/core/author | "Pan S.F."xsd:string |
| http://purl.uniprot.org/citations/25250328 | http://purl.uniprot.org/core/author | "Tang S.T."xsd:string |
| http://purl.uniprot.org/citations/25250328 | http://purl.uniprot.org/core/date | "2014"xsd:gYear |
| http://purl.uniprot.org/citations/25250328 | http://purl.uniprot.org/core/name | "Biomed Res Int"xsd:string |
| http://purl.uniprot.org/citations/25250328 | http://purl.uniprot.org/core/pages | "695797"xsd:string |
| http://purl.uniprot.org/citations/25250328 | http://purl.uniprot.org/core/title | "Inhibition of peroxisome proliferator-activated receptor gamma prevents the melanogenesis in murine B16/F10 melanoma cells."xsd:string |
| http://purl.uniprot.org/citations/25250328 | http://purl.uniprot.org/core/volume | "2014"xsd:string |
| http://purl.uniprot.org/citations/25250328 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/25250328 |
| http://purl.uniprot.org/citations/25250328 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/25250328 |
| http://purl.uniprot.org/uniprot/#_A0N0C8-mappedCitation-25250328 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25250328 |
| http://purl.uniprot.org/uniprot/#_A0N0D0-mappedCitation-25250328 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25250328 |
| http://purl.uniprot.org/uniprot/#_D0EPX6-mappedCitation-25250328 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25250328 |
| http://purl.uniprot.org/uniprot/#_D0EPX7-mappedCitation-25250328 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25250328 |
| http://purl.uniprot.org/uniprot/#_D0EPX9-mappedCitation-25250328 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25250328 |
| http://purl.uniprot.org/uniprot/#_P37238-mappedCitation-25250328 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25250328 |