| http://purl.uniprot.org/citations/25251667 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/25251667 | http://www.w3.org/2000/01/rdf-schema#comment | "In the accepted model of T-cell activation, parallel signal-transduction pathways activate the transcription factors NF-κB, NFAT, and AP-1 to drive clonal expansion of T cells in response to Ag. Genome-wide transcriptional profiling following Ag-induced CD8(+) T-cell activation in C57BL/6 mouse T cells revealed that genes regulated by NFAT were also reduced in the absence of NF-κB p50 and cRel subunits. Importantly, p50(-/-) cRel(-/-) CD8(+) T cells had significantly diminished NFAT and AP-1 activation compared with WT or PKCθ(-/-) CD8(+) T cells. Attenuated NFAT activation after TCR engagement was associated with reduced calcium influx, PLCγ and Zap70 activation. Interestingly, pharmacological bypass of PLCγ-regulated pathways largely rescued p50(-/-) cRel(-/-) T-cell proliferative defects. These results indicate a crucial and unexpected requirement for NF-κB p50 and cRel subunits in proximal TCR signaling and calcium responses. They further suggest that key defects in T cells in the absence of NF-κB pathway components may be due to impaired proximal T-cell signaling."xsd:string |
| http://purl.uniprot.org/citations/25251667 | http://purl.org/dc/terms/identifier | "doi:10.1002/eji.201444904"xsd:string |
| http://purl.uniprot.org/citations/25251667 | http://purl.uniprot.org/core/author | "Yang S."xsd:string |
| http://purl.uniprot.org/citations/25251667 | http://purl.uniprot.org/core/author | "Beg A.A."xsd:string |
| http://purl.uniprot.org/citations/25251667 | http://purl.uniprot.org/core/author | "Yoder S."xsd:string |
| http://purl.uniprot.org/citations/25251667 | http://purl.uniprot.org/core/author | "Yu X.Z."xsd:string |
| http://purl.uniprot.org/citations/25251667 | http://purl.uniprot.org/core/author | "Celis E."xsd:string |
| http://purl.uniprot.org/citations/25251667 | http://purl.uniprot.org/core/author | "Bronk C.C."xsd:string |
| http://purl.uniprot.org/citations/25251667 | http://purl.uniprot.org/core/author | "Hopewell E.L."xsd:string |
| http://purl.uniprot.org/citations/25251667 | http://purl.uniprot.org/core/date | "2014"xsd:gYear |
| http://purl.uniprot.org/citations/25251667 | http://purl.uniprot.org/core/name | "Eur J Immunol"xsd:string |
| http://purl.uniprot.org/citations/25251667 | http://purl.uniprot.org/core/pages | "3741-3746"xsd:string |
| http://purl.uniprot.org/citations/25251667 | http://purl.uniprot.org/core/title | "NF-kappaB is crucial in proximal T-cell signaling for calcium influx and NFAT activation."xsd:string |
| http://purl.uniprot.org/citations/25251667 | http://purl.uniprot.org/core/volume | "44"xsd:string |
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