| http://purl.uniprot.org/citations/25252899 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/25252899 | http://www.w3.org/2000/01/rdf-schema#comment | "Copeptin has been associated with the severity of pneumonia and its complications. This study was designed to assess the usefulness of copeptin measurement in children with community-acquired pneumonia (CAP) and copeptin's relation with disease severity and sodium equilibrium. The study encompassed 311 patients (227 with pneumonia and 84 healthy controls) aged 8 days-18 years. Clinical findings and inflammatory markers were used to predict the disease severity. We found that the level of copeptin was significantly higher in patients with CAP (median 0.88 ng/mL) vs. healthy children (0.33 ng/mL; p < 0.01). ROC analysis showed a high AUC value (0.87) and the cut-off point for plasma copeptin level was 0.44 ng/mL, with a high sensitivity (89 %) and specificity (73 %) in recognizing pneumonia. Patients with higher copeptin concentrations were at higher risk of hyponatremia (OR 2.43). Yet there was only a weak reverse correlation between the sodium and the copeptin concentrations (Spearmann's rank coefficient = -0.19). The levels of copeptin were higher in hyponatremic patients (0.83 ng/mL) vs. normonatremic patients (0.69 ng/mL; p = 0.02). Copeptin elevation did not reflect the CAP severity measured with traditionally used methods. In conclusion, copeptin elevation is a promising marker of pneumonia, but it reflects neither the disease severity nor sodium concentration."xsd:string |
| http://purl.uniprot.org/citations/25252899 | http://purl.org/dc/terms/identifier | "doi:10.1007/5584_2014_41"xsd:string |
| http://purl.uniprot.org/citations/25252899 | http://purl.uniprot.org/core/author | "Pawlik K."xsd:string |
| http://purl.uniprot.org/citations/25252899 | http://purl.uniprot.org/core/author | "Jackowska T."xsd:string |
| http://purl.uniprot.org/citations/25252899 | http://purl.uniprot.org/core/author | "Wrotek A."xsd:string |
| http://purl.uniprot.org/citations/25252899 | http://purl.uniprot.org/core/date | "2015"xsd:gYear |
| http://purl.uniprot.org/citations/25252899 | http://purl.uniprot.org/core/name | "Adv Exp Med Biol"xsd:string |
| http://purl.uniprot.org/citations/25252899 | http://purl.uniprot.org/core/pages | "31-36"xsd:string |
| http://purl.uniprot.org/citations/25252899 | http://purl.uniprot.org/core/title | "Sodium and copeptin levels in children with community acquired pneumonia."xsd:string |
| http://purl.uniprot.org/citations/25252899 | http://purl.uniprot.org/core/volume | "835"xsd:string |
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