| http://purl.uniprot.org/citations/25252945 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/25252945 | http://www.w3.org/2000/01/rdf-schema#comment | "In most animals, steroid hormones are crucial regulators of physiology and developmental life transitions. Steroid synthesis depends on extrinsic parameters and autoregulatory processes to fine-tune the dynamics of hormone production. In Drosophila, transient increases of the steroid prohormone ecdysone, produced at each larval stage, are necessary to trigger moulting and metamorphosis. Binding of the active ecdysone (20-hydroxyecdysone) to its receptor (EcR) is followed by the sequential expression of the nuclear receptors E75, DHR3 and βFtz-f1, representing a model for steroid hormone signalling. Here, we have combined genetic and imaging approaches to investigate the precise role of this signalling cascade within theprothoracic gland (PG), where ecdysone synthesis takes place. We show that these receptors operate through an apparent unconventional hierarchy in the PG to control ecdysone biosynthesis. At metamorphosis onset, DHR3 emerges as the downstream component that represses steroidogenic enzymes and requires an early effect of EcR for this repression. To avoid premature repression of steroidogenesis, E75 counteracts DHR3 activity, whereas EcR and βFtz-f1 act early in development through a forward process to moderate DHR3 levels. Our findings suggest that within the steroidogenic tissue, a given 20-hydroxyecdysone peak induces autoregulatory processes to sharpen ecdysone production and to confer competence for ecdysteroid biosynthesis at the next developmental phase, providing novel insights into steroid hormone kinetics."xsd:string |
| http://purl.uniprot.org/citations/25252945 | http://purl.org/dc/terms/identifier | "doi:10.1242/dev.102020"xsd:string |
| http://purl.uniprot.org/citations/25252945 | http://purl.uniprot.org/core/author | "Wang P."xsd:string |
| http://purl.uniprot.org/citations/25252945 | http://purl.uniprot.org/core/author | "Garrido D."xsd:string |
| http://purl.uniprot.org/citations/25252945 | http://purl.uniprot.org/core/author | "Parvy J.P."xsd:string |
| http://purl.uniprot.org/citations/25252945 | http://purl.uniprot.org/core/author | "Poidevin M."xsd:string |
| http://purl.uniprot.org/citations/25252945 | http://purl.uniprot.org/core/author | "Montagne J."xsd:string |
| http://purl.uniprot.org/citations/25252945 | http://purl.uniprot.org/core/author | "Blais C."xsd:string |
| http://purl.uniprot.org/citations/25252945 | http://purl.uniprot.org/core/author | "Maria A."xsd:string |
| http://purl.uniprot.org/citations/25252945 | http://purl.uniprot.org/core/date | "2014"xsd:gYear |
| http://purl.uniprot.org/citations/25252945 | http://purl.uniprot.org/core/name | "Development"xsd:string |
| http://purl.uniprot.org/citations/25252945 | http://purl.uniprot.org/core/pages | "3955-3965"xsd:string |
| http://purl.uniprot.org/citations/25252945 | http://purl.uniprot.org/core/title | "Forward and feedback regulation of cyclic steroid production in Drosophila melanogaster."xsd:string |
| http://purl.uniprot.org/citations/25252945 | http://purl.uniprot.org/core/volume | "141"xsd:string |
| http://purl.uniprot.org/citations/25252945 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/25252945 |
| http://purl.uniprot.org/citations/25252945 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/25252945 |
| http://purl.uniprot.org/uniprot/#_A0A0B4KEJ3-mappedCitation-25252945 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25252945 |
| http://purl.uniprot.org/uniprot/#_E1JGY2-mappedCitation-25252945 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25252945 |
| http://purl.uniprot.org/uniprot/#_A4UZ51-mappedCitation-25252945 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25252945 |
| http://purl.uniprot.org/uniprot/#_A8DY91-mappedCitation-25252945 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25252945 |
| http://purl.uniprot.org/uniprot/#_A0A0S0WH29-mappedCitation-25252945 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25252945 |
| http://purl.uniprot.org/uniprot/#_A0A0S0WIG6-mappedCitation-25252945 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25252945 |
| http://purl.uniprot.org/uniprot/#_A1Z858-mappedCitation-25252945 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25252945 |
| http://purl.uniprot.org/uniprot/#_A0A384SX09-mappedCitation-25252945 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25252945 |