| http://purl.uniprot.org/citations/25253721 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/25253721 | http://www.w3.org/2000/01/rdf-schema#comment | "The adherens junction (AJ) plays a crucial role in maintaining cell-cell adhesion in epithelial tissues. Previous studies show that KIFC3, a minus end-directed kinesin motor, moves into AJs via microtubules that grow from clusters of CAMSAP3 (also known as Nezha), a protein that binds microtubule minus ends. The function of junction-associated KIFC3, however, remains to be elucidated. Here we find that KIFC3 binds the ubiquitin-specific protease USP47, a protease that removes ubiquitin chains from substrates and hence inhibits proteasome-mediated proteolysis, and recruits it to AJs. Depletion of KIFC3 or USP47 promotes cleavage of E-cadherin at a juxtamembrane region of the cytoplasmic domain, resulting in the production of a 90-kDa fragment and the internalization of E-cadherin. This cleavage depends on the E3 ubiquitin protein ligase Hakai and is inhibited by proteasome inhibitors. E-cadherin ubiquitination consistently increases after depletion of KIFC3 or USP47. These findings suggest that KIFC3 suppresses the ubiquitination and resultant degradation of E-cadherin by recruiting USP47 to AJs, a process that may be involved in maintaining stable cell-cell adhesion in epithelial sheets."xsd:string |
| http://purl.uniprot.org/citations/25253721 | http://purl.org/dc/terms/identifier | "doi:10.1091/mbc.e14-07-1245"xsd:string |
| http://purl.uniprot.org/citations/25253721 | http://purl.uniprot.org/core/author | "Nagae S."xsd:string |
| http://purl.uniprot.org/citations/25253721 | http://purl.uniprot.org/core/author | "Tanaka N."xsd:string |
| http://purl.uniprot.org/citations/25253721 | http://purl.uniprot.org/core/author | "Takeichi M."xsd:string |
| http://purl.uniprot.org/citations/25253721 | http://purl.uniprot.org/core/author | "Meng W."xsd:string |
| http://purl.uniprot.org/citations/25253721 | http://purl.uniprot.org/core/author | "Sako-Kubota K."xsd:string |
| http://purl.uniprot.org/citations/25253721 | http://purl.uniprot.org/core/date | "2014"xsd:gYear |
| http://purl.uniprot.org/citations/25253721 | http://purl.uniprot.org/core/name | "Mol Biol Cell"xsd:string |
| http://purl.uniprot.org/citations/25253721 | http://purl.uniprot.org/core/pages | "3851-3860"xsd:string |
| http://purl.uniprot.org/citations/25253721 | http://purl.uniprot.org/core/title | "Minus end-directed motor KIFC3 suppresses E-cadherin degradation by recruiting USP47 to adherens junctions."xsd:string |
| http://purl.uniprot.org/citations/25253721 | http://purl.uniprot.org/core/volume | "25"xsd:string |
| http://purl.uniprot.org/citations/25253721 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/25253721 |
| http://purl.uniprot.org/citations/25253721 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/25253721 |
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| http://purl.uniprot.org/uniprot/#_A0A0E3XJU3-mappedCitation-25253721 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25253721 |
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