| http://purl.uniprot.org/citations/25255378 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/25255378 | http://www.w3.org/2000/01/rdf-schema#comment | "Sepsis is a major cause of acute kidney injury (AKI) with high rates of morbidity and mortality. Surfactant proteins A and D (SP-A, SP-D) play a critical role in host defense and regulate inflammation during infection. Recent studies indicate SP-A and SP-D are expressed in the kidney. The current study examines the role of SP-A and SP-D in the pathogenesis of sepsis-induced AKI. Wild-type (WT) and SP-A/SP-D double-knockout (KO) C57BL/6 mice were treated by cecal ligation and puncture (CLP) or sham surgery. Histological, cellular, and molecular indices of kidney injury were investigated in septic mice 6 and 24 h after CLP. Twenty-four hours after CLP, kidney injury was more severe, renal function was decreased, and blood creatinine and blood urea nitrogen were higher in septic SP-A/SP-D KO mice (P < 0.05, versus septic WT mice). Kidney edema and vascular permeability were increased in septic SP-A/SP-D KO mice (P < 0.01, versus septic WT mice). Apoptotic cells increased significantly (P < 0.01) in the kidney of septic SP-A/SP-D KO mice compared with septic WT mice. Molecular analysis revealed levels of Bcl-2 (an inhibitor of apoptosis) were lower and levels of caspase 3 (a biomarker of apoptosis) were higher in the kidney of septic SP-A/SP-D KO mice (P < 0.01, versus septic WT mice). Furthermore, levels of nuclear factor κB and phosphorylated IκB-α increased significantly in the kidney of septic SP-A/SP-D KO mice compared with septic WT mice, suggesting SP-A/SP-D KO mice have a more pronounced inflammatory response to sepsis. We conclude SP-A and SP-D attenuate kidney injury by modulating inflammation and apoptosis in sepsis-induced AKI."xsd:string |
| http://purl.uniprot.org/citations/25255378 | http://purl.org/dc/terms/identifier | "doi:10.1097/shk.0000000000000270"xsd:string |
| http://purl.uniprot.org/citations/25255378 | http://purl.uniprot.org/core/author | "Liu Z."xsd:string |
| http://purl.uniprot.org/citations/25255378 | http://purl.uniprot.org/core/author | "Liu J."xsd:string |
| http://purl.uniprot.org/citations/25255378 | http://purl.uniprot.org/core/author | "Wang G."xsd:string |
| http://purl.uniprot.org/citations/25255378 | http://purl.uniprot.org/core/author | "Zhou Q."xsd:string |
| http://purl.uniprot.org/citations/25255378 | http://purl.uniprot.org/core/author | "Hu F."xsd:string |
| http://purl.uniprot.org/citations/25255378 | http://purl.uniprot.org/core/author | "Cooney R.N."xsd:string |
| http://purl.uniprot.org/citations/25255378 | http://purl.uniprot.org/core/author | "Abdel-Razek O."xsd:string |
| http://purl.uniprot.org/citations/25255378 | http://purl.uniprot.org/core/date | "2015"xsd:gYear |
| http://purl.uniprot.org/citations/25255378 | http://purl.uniprot.org/core/name | "Shock"xsd:string |
| http://purl.uniprot.org/citations/25255378 | http://purl.uniprot.org/core/pages | "31-38"xsd:string |
| http://purl.uniprot.org/citations/25255378 | http://purl.uniprot.org/core/title | "Role of surfactant proteins A and D in sepsis-induced acute kidney injury."xsd:string |
| http://purl.uniprot.org/citations/25255378 | http://purl.uniprot.org/core/volume | "43"xsd:string |
| http://purl.uniprot.org/citations/25255378 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/25255378 |
| http://purl.uniprot.org/citations/25255378 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/25255378 |
| http://purl.uniprot.org/uniprot/#_P50404-mappedCitation-25255378 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25255378 |
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| http://purl.uniprot.org/uniprot/#_Q9CQI1-mappedCitation-25255378 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25255378 |
| http://purl.uniprot.org/uniprot/#_Q6P8S2-mappedCitation-25255378 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25255378 |
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| http://purl.uniprot.org/uniprot/Q9CQI1 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/25255378 |
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