| http://purl.uniprot.org/citations/25255805 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/25255805 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/25255805 | http://www.w3.org/2000/01/rdf-schema#comment | "Protein N-myristoylation is a ubiquitous co- and post-translational modification that has been implicated in the development and progression of a range of human diseases. Here, we report the global N-myristoylated proteome in human cells determined using quantitative chemical proteomics combined with potent and specific human N-myristoyltransferase (NMT) inhibition. Global quantification of N-myristoylation during normal growth or apoptosis allowed the identification of >100 N-myristoylated proteins, >95% of which are identified for the first time at endogenous levels. Furthermore, quantitative dose response for inhibition of N-myristoylation is determined for >70 substrates simultaneously across the proteome. Small-molecule inhibition through a conserved substrate-binding pocket is also demonstrated by solving the crystal structures of inhibitor-bound NMT1 and NMT2. The presented data substantially expand the known repertoire of co- and post-translational N-myristoylation in addition to validating tools for the pharmacological inhibition of NMT in living cells."xsd:string |
| http://purl.uniprot.org/citations/25255805 | http://purl.org/dc/terms/identifier | "doi:10.1038/ncomms5919"xsd:string |
| http://purl.uniprot.org/citations/25255805 | http://purl.org/dc/terms/identifier | "doi:10.1038/ncomms5919"xsd:string |
| http://purl.uniprot.org/citations/25255805 | http://purl.uniprot.org/core/author | "Broncel M."xsd:string |
| http://purl.uniprot.org/citations/25255805 | http://purl.uniprot.org/core/author | "Broncel M."xsd:string |
| http://purl.uniprot.org/citations/25255805 | http://purl.uniprot.org/core/author | "Mann D.J."xsd:string |
| http://purl.uniprot.org/citations/25255805 | http://purl.uniprot.org/core/author | "Mann D.J."xsd:string |
| http://purl.uniprot.org/citations/25255805 | http://purl.uniprot.org/core/author | "Wilkinson A.J."xsd:string |
| http://purl.uniprot.org/citations/25255805 | http://purl.uniprot.org/core/author | "Wilkinson A.J."xsd:string |
| http://purl.uniprot.org/citations/25255805 | http://purl.uniprot.org/core/author | "Brannigan J.A."xsd:string |
| http://purl.uniprot.org/citations/25255805 | http://purl.uniprot.org/core/author | "Brannigan J.A."xsd:string |
| http://purl.uniprot.org/citations/25255805 | http://purl.uniprot.org/core/author | "Tate E.W."xsd:string |
| http://purl.uniprot.org/citations/25255805 | http://purl.uniprot.org/core/author | "Tate E.W."xsd:string |
| http://purl.uniprot.org/citations/25255805 | http://purl.uniprot.org/core/author | "Brassat U."xsd:string |
| http://purl.uniprot.org/citations/25255805 | http://purl.uniprot.org/core/author | "Brassat U."xsd:string |
| http://purl.uniprot.org/citations/25255805 | http://purl.uniprot.org/core/author | "Heal W.P."xsd:string |
| http://purl.uniprot.org/citations/25255805 | http://purl.uniprot.org/core/author | "Heal W.P."xsd:string |
| http://purl.uniprot.org/citations/25255805 | http://purl.uniprot.org/core/author | "Serwa R.A."xsd:string |
| http://purl.uniprot.org/citations/25255805 | http://purl.uniprot.org/core/author | "Serwa R.A."xsd:string |
| http://purl.uniprot.org/citations/25255805 | http://purl.uniprot.org/core/author | "Thinon E."xsd:string |
| http://purl.uniprot.org/citations/25255805 | http://purl.uniprot.org/core/author | "Thinon E."xsd:string |
| http://purl.uniprot.org/citations/25255805 | http://purl.uniprot.org/core/author | "Wright M.H."xsd:string |
| http://purl.uniprot.org/citations/25255805 | http://purl.uniprot.org/core/author | "Wright M.H."xsd:string |