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http://purl.uniprot.org/citations/25257838http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
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Background

B cell lymphoma 2 (BCL-2) gene is a well-known regulator of apoptosis and a key element in cancer development and progression. A regulatory (-938C>A, rs2279115) single-nucleotide polymorphism in the inhibitory P2 BCL-2 gene promoter generates significantly different BCL-2 promoter activities and has been associated with different clinical outcomes in various malignancies. The aim of the present study was to analyze the possible influence of the (-938C>A) SNP on the risk and survival of Indian patients suffering from NSCLC.

Materials and methods

A hospital-based case-control study of 155 age- and sex-matched patients diagnosed with NSCLC and 155 cancer-free controls was conducted and genotyped by performing PIRA-PCR to elucidate the putative association between clinical outcome and genotypes of BCL-2 (-938C>A, rs2279115). The association of the polymorphism with the survival of NSCLC patients was analyzed by Kaplan-Meier curves.

Results

In Indian NSCLC, patients increased risk of developing NSCLC was found to be associated with BCL-2 (-938) CC genotype, [OR 3.68 (1.92-6.79), RR 1.87 (1.35-2.57) and RD 31.03 (16.79-45.27) p 0.00006 for CC and OR 2.08 (1.18-3.66), RR 1.36 (1.08-1.71) and RD 17.74 (4.68-30.81) p 0.01 for AC genotype]. Patients homozygous for C allele exhibited a significant poor overall survival compared with patients displaying AC + CC or AC or AA genotype [median survival (months) 8 vs. 11 vs. 14 vs. 35.5 (p < 0.0001)]. In addition, significant associations were observed between TNM stage, histological type, distant metastases status, family history of any cancer, gender and age group of NSCLC patients with BCL-2 (-938C>A) polymorphism.

Conclusion

Genetic polymorphism in the inhibitory P2 promoter region of anti-apoptotic BCL-2 genes contributes to the risk of developing non-small-cell lung cancer in Indian population. BCL-2 (-938CC) genotype was an independent adverse prognostic factor for patients with NSCLC."xsd:string
http://purl.uniprot.org/citations/25257838http://purl.org/dc/terms/identifier"doi:10.1007/s12094-014-1226-2"xsd:string
http://purl.uniprot.org/citations/25257838http://purl.uniprot.org/core/author"Mir R."xsd:string
http://purl.uniprot.org/citations/25257838http://purl.uniprot.org/core/author"Ray P.C."xsd:string
http://purl.uniprot.org/citations/25257838http://purl.uniprot.org/core/author"Saxena A."xsd:string
http://purl.uniprot.org/citations/25257838http://purl.uniprot.org/core/author"Mirza M."xsd:string
http://purl.uniprot.org/citations/25257838http://purl.uniprot.org/core/author"Mohan A."xsd:string
http://purl.uniprot.org/citations/25257838http://purl.uniprot.org/core/author"Lone M."xsd:string
http://purl.uniprot.org/citations/25257838http://purl.uniprot.org/core/author"Julka P.K."xsd:string
http://purl.uniprot.org/citations/25257838http://purl.uniprot.org/core/author"Javid J."xsd:string
http://purl.uniprot.org/citations/25257838http://purl.uniprot.org/core/author"Imtiyaz A."xsd:string
http://purl.uniprot.org/citations/25257838http://purl.uniprot.org/core/author"Mariyam Z."xsd:string
http://purl.uniprot.org/citations/25257838http://purl.uniprot.org/core/author"Prasant Y."xsd:string
http://purl.uniprot.org/citations/25257838http://purl.uniprot.org/core/date"2015"xsd:gYear
http://purl.uniprot.org/citations/25257838http://purl.uniprot.org/core/name"Clin Transl Oncol"xsd:string
http://purl.uniprot.org/citations/25257838http://purl.uniprot.org/core/pages"289-295"xsd:string
http://purl.uniprot.org/citations/25257838http://purl.uniprot.org/core/title"CC genotype of anti-apoptotic gene BCL-2 (-938 C/A) is an independent prognostic marker of unfavorable clinical outcome in patients with non-small-cell lung cancer."xsd:string
http://purl.uniprot.org/citations/25257838http://purl.uniprot.org/core/volume"17"xsd:string
http://purl.uniprot.org/citations/25257838http://www.w3.org/2004/02/skos/core#exactMatchhttp://purl.uniprot.org/pubmed/25257838
http://purl.uniprot.org/citations/25257838http://xmlns.com/foaf/0.1/primaryTopicOfhttps://pubmed.ncbi.nlm.nih.gov/25257838
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