| http://purl.uniprot.org/citations/25258341 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/25258341 | http://www.w3.org/2000/01/rdf-schema#comment | "NBEAL2 encodes a multidomain scaffolding protein with a putative role in granule ontogeny in human platelets. Mutations in NBEAL2 underlie gray platelet syndrome (GPS), a rare inherited bleeding disorder characterized by a lack of α-granules within blood platelets and progressive bone marrow fibrosis. We present here a novel Nbeal2(-/-) murine model of GPS and demonstrate that the lack of α-granules is due to their loss from platelets/mature megakaryocytes (MKs), and not by initial impaired formation. We show that the lack of Nbeal2 confers a proinflammatory phenotype to the bone marrow MKs, which in combination with the loss of proteins from α-granules drives the development of bone marrow fibrosis. In addition, we demonstrate that α-granule deficiency impairs platelet function beyond their purely hemostatic role and that Nbeal2 deficiency has a protective effect against cancer metastasis."xsd:string |
| http://purl.uniprot.org/citations/25258341 | http://purl.org/dc/terms/identifier | "doi:10.1182/blood-2014-04-566760"xsd:string |
| http://purl.uniprot.org/citations/25258341 | http://purl.uniprot.org/core/author | "Speak A.O."xsd:string |
| http://purl.uniprot.org/citations/25258341 | http://purl.uniprot.org/core/author | "Rendon A."xsd:string |
| http://purl.uniprot.org/citations/25258341 | http://purl.uniprot.org/core/author | "Chin M."xsd:string |
| http://purl.uniprot.org/citations/25258341 | http://purl.uniprot.org/core/author | "van der Weyden L."xsd:string |
| http://purl.uniprot.org/citations/25258341 | http://purl.uniprot.org/core/author | "Bennett C."xsd:string |
| http://purl.uniprot.org/citations/25258341 | http://purl.uniprot.org/core/author | "Ouwehand W.H."xsd:string |
| http://purl.uniprot.org/citations/25258341 | http://purl.uniprot.org/core/author | "Erber W.N."xsd:string |
| http://purl.uniprot.org/citations/25258341 | http://purl.uniprot.org/core/author | "Nurden P."xsd:string |
| http://purl.uniprot.org/citations/25258341 | http://purl.uniprot.org/core/author | "Ghevaert C."xsd:string |
| http://purl.uniprot.org/citations/25258341 | http://purl.uniprot.org/core/author | "Guerrero J.A."xsd:string |
| http://purl.uniprot.org/citations/25258341 | http://purl.uniprot.org/core/author | "Wardle-Jones H."xsd:string |
| http://purl.uniprot.org/citations/25258341 | http://purl.uniprot.org/core/author | "Estabel J."xsd:string |
| http://purl.uniprot.org/citations/25258341 | http://purl.uniprot.org/core/author | "McKinney H."xsd:string |
| http://purl.uniprot.org/citations/25258341 | http://purl.uniprot.org/core/author | "Cambridge E.L."xsd:string |
| http://purl.uniprot.org/citations/25258341 | http://purl.uniprot.org/core/author | "McIntyre Z."xsd:string |
| http://purl.uniprot.org/citations/25258341 | http://purl.uniprot.org/core/date | "2014"xsd:gYear |
| http://purl.uniprot.org/citations/25258341 | http://purl.uniprot.org/core/name | "Blood"xsd:string |
| http://purl.uniprot.org/citations/25258341 | http://purl.uniprot.org/core/pages | "3624-3635"xsd:string |
| http://purl.uniprot.org/citations/25258341 | http://purl.uniprot.org/core/title | "Gray platelet syndrome: proinflammatory megakaryocytes and alpha-granule loss cause myelofibrosis and confer metastasis resistance in mice."xsd:string |
| http://purl.uniprot.org/citations/25258341 | http://purl.uniprot.org/core/volume | "124"xsd:string |
| http://purl.uniprot.org/citations/25258341 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/25258341 |
| http://purl.uniprot.org/citations/25258341 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/25258341 |