| http://purl.uniprot.org/citations/25260751 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/25260751 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/25260751 | http://www.w3.org/2000/01/rdf-schema#comment | "Unlike the other MAP3Ks, MEKK1 (encoded by Map3k1) contains a PHD motif. To understand the role of this motif, we have created a knockin mutant of mouse Map3k1 (Map3k1(m) (PHD)) with an inactive PHD motif. Map3k1(m) (PHD) ES cells demonstrate that the MEKK1 PHD controls p38 and JNK activation during TGF-β, EGF and microtubule disruption signalling, but does not affect MAPK responses to hyperosmotic stress. Protein microarray profiling identified the adaptor TAB1 as a PHD substrate, and TGF-β- or EGF-stimulated Map3k1(m) (PHD) ES cells exhibit defective non-canonical ubiquitination of MEKK1 and TAB1. The MEKK1 PHD binds and mediates the transfer of Lys63-linked poly-Ub, using the conjugating enzyme UBE2N, onto TAB1 to regulate TAK1 and MAPK activation by TGF-β and EGF. Both the MEKK1 PHD and TAB1 are critical for ES-cell differentiation and tumourigenesis. Map3k1(m) (PHD) (/+) mice exhibit aberrant cardiac tissue, B-cell development, testis and T-cell signalling."xsd:string |
| http://purl.uniprot.org/citations/25260751 | http://purl.org/dc/terms/identifier | "doi:10.15252/embj.201488351"xsd:string |
| http://purl.uniprot.org/citations/25260751 | http://purl.org/dc/terms/identifier | "doi:10.15252/embj.201488351"xsd:string |
| http://purl.uniprot.org/citations/25260751 | http://purl.uniprot.org/core/author | "Wu X."xsd:string |
| http://purl.uniprot.org/citations/25260751 | http://purl.uniprot.org/core/author | "Wu X."xsd:string |
| http://purl.uniprot.org/citations/25260751 | http://purl.uniprot.org/core/author | "Anwar S."xsd:string |
| http://purl.uniprot.org/citations/25260751 | http://purl.uniprot.org/core/author | "Anwar S."xsd:string |
| http://purl.uniprot.org/citations/25260751 | http://purl.uniprot.org/core/author | "Karin M."xsd:string |
| http://purl.uniprot.org/citations/25260751 | http://purl.uniprot.org/core/author | "Karin M."xsd:string |
| http://purl.uniprot.org/citations/25260751 | http://purl.uniprot.org/core/author | "Gallagher E."xsd:string |
| http://purl.uniprot.org/citations/25260751 | http://purl.uniprot.org/core/author | "Gallagher E."xsd:string |
| http://purl.uniprot.org/citations/25260751 | http://purl.uniprot.org/core/author | "Charlaftis N."xsd:string |
| http://purl.uniprot.org/citations/25260751 | http://purl.uniprot.org/core/author | "Charlaftis N."xsd:string |
| http://purl.uniprot.org/citations/25260751 | http://purl.uniprot.org/core/author | "Suddason T."xsd:string |
| http://purl.uniprot.org/citations/25260751 | http://purl.uniprot.org/core/author | "Suddason T."xsd:string |
| http://purl.uniprot.org/citations/25260751 | http://purl.uniprot.org/core/date | "2014"xsd:gYear |
| http://purl.uniprot.org/citations/25260751 | http://purl.uniprot.org/core/date | "2014"xsd:gYear |
| http://purl.uniprot.org/citations/25260751 | http://purl.uniprot.org/core/name | "EMBO J."xsd:string |
| http://purl.uniprot.org/citations/25260751 | http://purl.uniprot.org/core/name | "EMBO J."xsd:string |
| http://purl.uniprot.org/citations/25260751 | http://purl.uniprot.org/core/pages | "2581-2596"xsd:string |
| http://purl.uniprot.org/citations/25260751 | http://purl.uniprot.org/core/pages | "2581-2596"xsd:string |
| http://purl.uniprot.org/citations/25260751 | http://purl.uniprot.org/core/title | "The MEKK1 PHD ubiquitinates TAB1 to activate MAPKs in response to cytokines."xsd:string |
| http://purl.uniprot.org/citations/25260751 | http://purl.uniprot.org/core/title | "The MEKK1 PHD ubiquitinates TAB1 to activate MAPKs in response to cytokines."xsd:string |