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| http://purl.uniprot.org/citations/25260918 | http://www.w3.org/2000/01/rdf-schema#comment | "Neurofilaments (NFs) are thought to provide structural support to mature axons via crosslinking of cytoskeletal elements mediated by the C-terminal region of the high molecular weight NF subunit (NF-H). Herein, we inhibited NF-H expression in differentiating mouse NB2a/d1 cells with shRNA directed against murine NF-H without affecting other NF subunits, microtubules or actin. shRNA-mediated NF-H knockdown not only in compromised of late-stage axonal neurite stabilization but also compromised early stages of axonal neurite elongation. Expression of exogenous rat NF-H was able to compensate for knockdown of endogenous NF-H and restored the development and stabilization of axonal neurites. This rescue was prevented by simultaneous treatment with shRNA that inhibited both rat and murine NF-H, or by expression of exogenous rat NF-H lacking the C-terminal sidearm during knockdown of endogenous NF-H. Demonstration of a role for NF-H in the early stages of axonal elaboration suggests that axonal stabilization is not delayed until synaptogenesis, but rather that the developing axon undergoes sequential NF-H-mediated stabilization along its length in a proximal-distal manner, which supports continued pathfinding in distal, unstabilized regions."xsd:string |
| http://purl.uniprot.org/citations/25260918 | http://purl.org/dc/terms/identifier | "doi:10.1242/bio.20149779"xsd:string |
| http://purl.uniprot.org/citations/25260918 | http://purl.uniprot.org/core/author | "Lee S."xsd:string |
| http://purl.uniprot.org/citations/25260918 | http://purl.uniprot.org/core/author | "Shea T.B."xsd:string |
| http://purl.uniprot.org/citations/25260918 | http://purl.uniprot.org/core/date | "2014"xsd:gYear |
| http://purl.uniprot.org/citations/25260918 | http://purl.uniprot.org/core/name | "Biol Open"xsd:string |
| http://purl.uniprot.org/citations/25260918 | http://purl.uniprot.org/core/pages | "974-981"xsd:string |
| http://purl.uniprot.org/citations/25260918 | http://purl.uniprot.org/core/title | "The high molecular weight neurofilament subunit plays an essential role in axonal outgrowth and stabilization."xsd:string |
| http://purl.uniprot.org/citations/25260918 | http://purl.uniprot.org/core/volume | "3"xsd:string |
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