| http://purl.uniprot.org/citations/25263091 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/25263091 | http://www.w3.org/2000/01/rdf-schema#comment | "l-Afadin was originally purified from rat brain as an actin filament (F-actin)-binding protein that was homologous to the AF-6 gene product. Concomitantly, s-afadin that did not show an F-actin-binding capability was copurified with l-afadin. Structurally, s-afadin lacks the C-terminal F-actin-binding domain but has two short sequences that were not present in l-afadin. The properties and roles of l-afadin have intensively been investigated, but those of s-afadin have poorly been understood. We show here an additional difference in their biochemical properties other than binding to F-actin between l-afadin and s-afadin. Both l-afadin and s-afadin bound to nectins, immunoglobulin-like cell adhesion molecules, whereas s-afadin more preferentially bound to nectins than l-afadin. The PDZ domain of l-afadin and s-afadin was essential for their binding to nectin-3. The dilute domain of l-afadin negatively regulated its binding to nectin-3, but the deletion of the C-terminal F-actin-binding domain of l-afadin did not increase the binding of l-afadin to nectin-3. These results indicate that the s-afadin-specific C-terminal inserts may be involved in its preference of binding to nectin-3 and raise the possibility that there are proteins other than nectins that more preferentially bind s-afadin than l-afadin."xsd:string |
| http://purl.uniprot.org/citations/25263091 | http://purl.org/dc/terms/identifier | "doi:10.1111/gtc.12185"xsd:string |
| http://purl.uniprot.org/citations/25263091 | http://purl.uniprot.org/core/author | "Takai Y."xsd:string |
| http://purl.uniprot.org/citations/25263091 | http://purl.uniprot.org/core/author | "Maruo T."xsd:string |
| http://purl.uniprot.org/citations/25263091 | http://purl.uniprot.org/core/author | "Kobayashi R."xsd:string |
| http://purl.uniprot.org/citations/25263091 | http://purl.uniprot.org/core/author | "Kurita S."xsd:string |
| http://purl.uniprot.org/citations/25263091 | http://purl.uniprot.org/core/author | "Mandai K."xsd:string |
| http://purl.uniprot.org/citations/25263091 | http://purl.uniprot.org/core/author | "Miyata M."xsd:string |
| http://purl.uniprot.org/citations/25263091 | http://purl.uniprot.org/core/author | "Rikitake Y."xsd:string |
| http://purl.uniprot.org/citations/25263091 | http://purl.uniprot.org/core/date | "2014"xsd:gYear |
| http://purl.uniprot.org/citations/25263091 | http://purl.uniprot.org/core/name | "Genes Cells"xsd:string |
| http://purl.uniprot.org/citations/25263091 | http://purl.uniprot.org/core/pages | "853-863"xsd:string |
| http://purl.uniprot.org/citations/25263091 | http://purl.uniprot.org/core/title | "s-Afadin binds more preferentially to the cell adhesion molecules nectins than l-afadin."xsd:string |
| http://purl.uniprot.org/citations/25263091 | http://purl.uniprot.org/core/volume | "19"xsd:string |
| http://purl.uniprot.org/citations/25263091 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/25263091 |
| http://purl.uniprot.org/citations/25263091 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/25263091 |
| http://purl.uniprot.org/uniprot/#_D3Z7L2-mappedCitation-25263091 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25263091 |
| http://purl.uniprot.org/uniprot/#_E9Q9C3-mappedCitation-25263091 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25263091 |
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| http://purl.uniprot.org/uniprot/#_E9Q852-mappedCitation-25263091 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25263091 |
| http://purl.uniprot.org/uniprot/#_F6UII7-mappedCitation-25263091 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25263091 |
| http://purl.uniprot.org/uniprot/#_D3YUD2-mappedCitation-25263091 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25263091 |