| http://purl.uniprot.org/citations/25263124 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/25263124 | http://www.w3.org/2000/01/rdf-schema#comment | "Positive selection of diverse yet self-tolerant thymocytes is vital to immunity and requires a limited degree of T cell antigen receptor (TCR) signaling in response to self peptide-major histocompatibility complexes (self peptide-MHCs). Affinity of newly generated TCR for peptide-MHC primarily sets the boundaries for positive selection. We report that N-glycan branching of TCR and the CD4 and CD8 coreceptors separately altered the upper and lower affinity boundaries from which interactions between peptide-MHC and TCR positively select T cells. During thymocyte development, N-glycan branching varied approximately 15-fold. N-glycan branching was required for positive selection and decoupled Lck signaling from TCR-driven Ca(2+) flux to simultaneously promote low-affinity peptide-MHC responses while inhibiting high-affinity ones. Therefore, N-glycan branching imposes a sliding scale on interactions between peptide-MHC and TCR that bidirectionally expands the affinity range for positive selection."xsd:string |
| http://purl.uniprot.org/citations/25263124 | http://purl.org/dc/terms/identifier | "doi:10.1038/ni.3007"xsd:string |
| http://purl.uniprot.org/citations/25263124 | http://purl.uniprot.org/core/author | "Chen D."xsd:string |
| http://purl.uniprot.org/citations/25263124 | http://purl.uniprot.org/core/author | "Hong A."xsd:string |
| http://purl.uniprot.org/citations/25263124 | http://purl.uniprot.org/core/author | "Grigorian A."xsd:string |
| http://purl.uniprot.org/citations/25263124 | http://purl.uniprot.org/core/author | "Demetriou M."xsd:string |
| http://purl.uniprot.org/citations/25263124 | http://purl.uniprot.org/core/author | "Arakelyan A."xsd:string |
| http://purl.uniprot.org/citations/25263124 | http://purl.uniprot.org/core/author | "Mkhikian H."xsd:string |
| http://purl.uniprot.org/citations/25263124 | http://purl.uniprot.org/core/author | "Zhou R.W."xsd:string |
| http://purl.uniprot.org/citations/25263124 | http://purl.uniprot.org/core/date | "2014"xsd:gYear |
| http://purl.uniprot.org/citations/25263124 | http://purl.uniprot.org/core/name | "Nat Immunol"xsd:string |
| http://purl.uniprot.org/citations/25263124 | http://purl.uniprot.org/core/pages | "1038-1045"xsd:string |
| http://purl.uniprot.org/citations/25263124 | http://purl.uniprot.org/core/title | "N-glycosylation bidirectionally extends the boundaries of thymocyte positive selection by decoupling Lck from Ca^2⁺ signaling."xsd:string |
| http://purl.uniprot.org/citations/25263124 | http://purl.uniprot.org/core/volume | "15"xsd:string |
| http://purl.uniprot.org/citations/25263124 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/25263124 |
| http://purl.uniprot.org/citations/25263124 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/25263124 |
| http://purl.uniprot.org/uniprot/#_A0A1D8M9B3-mappedCitation-25263124 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25263124 |
| http://purl.uniprot.org/uniprot/#_A0A494B9G5-mappedCitation-25263124 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25263124 |
| http://purl.uniprot.org/uniprot/#_A0A494B9U2-mappedCitation-25263124 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25263124 |
| http://purl.uniprot.org/uniprot/#_P06342-mappedCitation-25263124 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25263124 |
| http://purl.uniprot.org/uniprot/#_P06343-mappedCitation-25263124 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25263124 |
| http://purl.uniprot.org/uniprot/#_P06345-mappedCitation-25263124 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25263124 |
| http://purl.uniprot.org/uniprot/#_P06346-mappedCitation-25263124 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25263124 |
| http://purl.uniprot.org/uniprot/#_Q31135-mappedCitation-25263124 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25263124 |