| http://purl.uniprot.org/citations/25263126 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/25263126 | http://www.w3.org/2000/01/rdf-schema#comment | "Chaperone-mediated autophagy (CMA) targets soluble proteins for lysosomal degradation. Here we found that CMA was activated in T cells in response to engagement of the T cell antigen receptor (TCR), which induced expression of the CMA-related lysosomal receptor LAMP-2A. In activated T cells, CMA targeted the ubiquitin ligase Itch and the calcineurin inhibitor RCAN1 for degradation to maintain activation-induced responses. Consequently, deletion of the gene encoding LAMP-2A in T cells caused deficient in vivo responses to immunization or infection with Listeria monocytogenes. Impaired CMA activity also occurred in T cells with age, which negatively affected their function. Restoration of LAMP-2A in T cells from old mice resulted in enhancement of activation-induced responses. Our findings define a role for CMA in regulating T cell activation through the targeted degradation of negative regulators of T cell activation."xsd:string |
| http://purl.uniprot.org/citations/25263126 | http://purl.org/dc/terms/identifier | "doi:10.1038/ni.3003"xsd:string |
| http://purl.uniprot.org/citations/25263126 | http://purl.uniprot.org/core/author | "Koga H."xsd:string |
| http://purl.uniprot.org/citations/25263126 | http://purl.uniprot.org/core/author | "Cuervo A.M."xsd:string |
| http://purl.uniprot.org/citations/25263126 | http://purl.uniprot.org/core/author | "Mocholi E."xsd:string |
| http://purl.uniprot.org/citations/25263126 | http://purl.uniprot.org/core/author | "Chandra D."xsd:string |
| http://purl.uniprot.org/citations/25263126 | http://purl.uniprot.org/core/author | "Macian F."xsd:string |
| http://purl.uniprot.org/citations/25263126 | http://purl.uniprot.org/core/author | "Gravekamp C."xsd:string |
| http://purl.uniprot.org/citations/25263126 | http://purl.uniprot.org/core/author | "Valdor R."xsd:string |
| http://purl.uniprot.org/citations/25263126 | http://purl.uniprot.org/core/author | "Botbol Y."xsd:string |
| http://purl.uniprot.org/citations/25263126 | http://purl.uniprot.org/core/author | "Guerrero-Ros I."xsd:string |
| http://purl.uniprot.org/citations/25263126 | http://purl.uniprot.org/core/date | "2014"xsd:gYear |
| http://purl.uniprot.org/citations/25263126 | http://purl.uniprot.org/core/name | "Nat Immunol"xsd:string |
| http://purl.uniprot.org/citations/25263126 | http://purl.uniprot.org/core/pages | "1046-1054"xsd:string |
| http://purl.uniprot.org/citations/25263126 | http://purl.uniprot.org/core/title | "Chaperone-mediated autophagy regulates T cell responses through targeted degradation of negative regulators of T cell activation."xsd:string |
| http://purl.uniprot.org/citations/25263126 | http://purl.uniprot.org/core/volume | "15"xsd:string |
| http://purl.uniprot.org/citations/25263126 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/25263126 |
| http://purl.uniprot.org/citations/25263126 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/25263126 |
| http://purl.uniprot.org/uniprot/#_Q3UIW3-mappedCitation-25263126 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25263126 |
| http://purl.uniprot.org/uniprot/#_P17047-mappedCitation-25263126 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25263126 |
| http://purl.uniprot.org/uniprot/#_Q3TWE1-mappedCitation-25263126 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25263126 |
| http://purl.uniprot.org/uniprot/#_Q8C5K0-mappedCitation-25263126 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25263126 |
| http://purl.uniprot.org/uniprot/#_Q8C876-mappedCitation-25263126 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25263126 |
| http://purl.uniprot.org/uniprot/#_Q9CZU7-mappedCitation-25263126 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25263126 |