| http://purl.uniprot.org/citations/25265021 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/25265021 | http://www.w3.org/2000/01/rdf-schema#comment | "Lifespan regulation by mitochondrial proteins has been well described, however, the mechanism of this regulation is not fully understood. Amongst the mitochondrial proteins profoundly affecting ageing are prohibitins (PHB-1 and PHB-2). Paradoxically, in C. elegans prohibitin depletion shortens the lifespan of wild type animals while dramatically extending that of metabolically compromised animals, such as daf-2-insulin-receptor mutants. Here we show that amongst the three kinases known to act downstream of daf-2, only loss of function of sgk-1 recapitulates the ageing phenotype observed in daf-2 mutants upon prohibitin depletion. Interestingly, signalling through SGK-1 receives input from an additional pathway, parallel to DAF-2, for the prohibitin-mediated lifespan phenotype. We investigated the effect of prohibitin depletion on the mitochondrial unfolded protein response (UPRmt). Remarkably, the lifespan extension upon prohibitin elimination, of both daf-2 and sgk-1 mutants, is accompanied by suppression of the UPRmt induced by lack of prohibitin. On the contrary, gain of function of SGK-1 results in further shortening of lifespan and a further increase of the UPRmt in prohibitin depleted animals. Moreover, SGK-1 interacts with RICT-1 for the regulation of the UPRmt in a parallel pathway to DAF-2. Interestingly, prohibitin depletion in rict-1 loss of function mutant animals also causes lifespan extension. Finally, we reveal an unprecedented role for mTORC2-SGK-1 in the regulation of mitochodrial homeostasis. Together, these results give further insight into the mechanism of lifespan regulation by mitochondrial function and reveal a cross-talk of mitochondria with two key pathways, Insulin/IGF and mTORC2, for the regulation of ageing and stress response."xsd:string |
| http://purl.uniprot.org/citations/25265021 | http://purl.org/dc/terms/identifier | "doi:10.1371/journal.pone.0107671"xsd:string |
| http://purl.uniprot.org/citations/25265021 | http://purl.uniprot.org/core/author | "Schulze B."xsd:string |
| http://purl.uniprot.org/citations/25265021 | http://purl.uniprot.org/core/author | "Baumeister R."xsd:string |
| http://purl.uniprot.org/citations/25265021 | http://purl.uniprot.org/core/author | "Artal-Sanz M."xsd:string |
| http://purl.uniprot.org/citations/25265021 | http://purl.uniprot.org/core/author | "Rodriguez-Palero M.J."xsd:string |
| http://purl.uniprot.org/citations/25265021 | http://purl.uniprot.org/core/author | "Gatsi R."xsd:string |
| http://purl.uniprot.org/citations/25265021 | http://purl.uniprot.org/core/author | "Hernando-Rodriguez B."xsd:string |
| http://purl.uniprot.org/citations/25265021 | http://purl.uniprot.org/core/date | "2014"xsd:gYear |
| http://purl.uniprot.org/citations/25265021 | http://purl.uniprot.org/core/name | "PLoS One"xsd:string |
| http://purl.uniprot.org/citations/25265021 | http://purl.uniprot.org/core/pages | "e107671"xsd:string |
| http://purl.uniprot.org/citations/25265021 | http://purl.uniprot.org/core/title | "Prohibitin-mediated lifespan and mitochondrial stress implicate SGK-1, insulin/IGF and mTORC2 in C. elegans."xsd:string |
| http://purl.uniprot.org/citations/25265021 | http://purl.uniprot.org/core/volume | "9"xsd:string |
| http://purl.uniprot.org/citations/25265021 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/25265021 |
| http://purl.uniprot.org/citations/25265021 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/25265021 |
| http://purl.uniprot.org/uniprot/#_A0A0K3AXA0-mappedCitation-25265021 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25265021 |
| http://purl.uniprot.org/uniprot/#_A0A0K3ARE8-mappedCitation-25265021 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25265021 |
| http://purl.uniprot.org/uniprot/#_A0A0K3ARZ1-mappedCitation-25265021 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25265021 |
| http://purl.uniprot.org/uniprot/#_A0A0K3AUA1-mappedCitation-25265021 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25265021 |
| http://purl.uniprot.org/uniprot/#_G5ED67-mappedCitation-25265021 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25265021 |
| http://purl.uniprot.org/uniprot/#_P50093-mappedCitation-25265021 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25265021 |
| http://purl.uniprot.org/uniprot/#_Q2PJ68-mappedCitation-25265021 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25265021 |
| http://purl.uniprot.org/uniprot/#_G5EFK2-mappedCitation-25265021 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25265021 |
| http://purl.uniprot.org/uniprot/#_G5EFN2-mappedCitation-25265021 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25265021 |