| http://purl.uniprot.org/citations/25270598 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/25270598 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/25270598 | http://www.w3.org/2000/01/rdf-schema#comment | "Primary cilia are microtubule-based sensory organelles that organize numerous key signals during developments and tissue homeostasis. Ciliary microtubule doublet, named axoneme, is grown directly from the distal end of mother centrioles through a multistep process upon cell cycle exit; however, the instructive signals that initiate these events are poorly understood. Here we show that ubiquitin-proteasome machinery removes trichoplein, a negative regulator of ciliogenesis, from mother centrioles and thereby causes Aurora-A inactivation, leading to ciliogenesis. Ciliogenesis is blocked if centriolar trichoplein is stabilized by treatment with proteasome inhibitors or by expression of non-ubiquitylatable trichoplein mutant (K50/57R). Started from two-stepped global E3 screening, we have identified KCTD17 as a substrate-adaptor for Cul3-RING E3 ligases (CRL3s) that polyubiquitylates trichoplein. Depletion of KCTD17 specifically arrests ciliogenesis at the initial step of axoneme extension through aberrant trichoplein-Aurora-A activity. Thus, CRL3-KCTD17 targets trichoplein to proteolysis to initiate the axoneme extension during ciliogenesis."xsd:string |
| http://purl.uniprot.org/citations/25270598 | http://purl.org/dc/terms/identifier | "doi:10.1038/ncomms6081"xsd:string |
| http://purl.uniprot.org/citations/25270598 | http://purl.org/dc/terms/identifier | "doi:10.1038/ncomms6081"xsd:string |
| http://purl.uniprot.org/citations/25270598 | http://purl.uniprot.org/core/author | "Goshima N."xsd:string |
| http://purl.uniprot.org/citations/25270598 | http://purl.uniprot.org/core/author | "Goshima N."xsd:string |
| http://purl.uniprot.org/citations/25270598 | http://purl.uniprot.org/core/author | "Kawamura Y."xsd:string |
| http://purl.uniprot.org/citations/25270598 | http://purl.uniprot.org/core/author | "Kawamura Y."xsd:string |
| http://purl.uniprot.org/citations/25270598 | http://purl.uniprot.org/core/author | "Kiyono T."xsd:string |
| http://purl.uniprot.org/citations/25270598 | http://purl.uniprot.org/core/author | "Kiyono T."xsd:string |
| http://purl.uniprot.org/citations/25270598 | http://purl.uniprot.org/core/author | "Inagaki M."xsd:string |
| http://purl.uniprot.org/citations/25270598 | http://purl.uniprot.org/core/author | "Inagaki M."xsd:string |
| http://purl.uniprot.org/citations/25270598 | http://purl.uniprot.org/core/author | "Kawakami Y."xsd:string |
| http://purl.uniprot.org/citations/25270598 | http://purl.uniprot.org/core/author | "Kawakami Y."xsd:string |
| http://purl.uniprot.org/citations/25270598 | http://purl.uniprot.org/core/author | "Kasahara K."xsd:string |
| http://purl.uniprot.org/citations/25270598 | http://purl.uniprot.org/core/author | "Kasahara K."xsd:string |
| http://purl.uniprot.org/citations/25270598 | http://purl.uniprot.org/core/author | "Matsuzaki F."xsd:string |
| http://purl.uniprot.org/citations/25270598 | http://purl.uniprot.org/core/author | "Matsuzaki F."xsd:string |
| http://purl.uniprot.org/citations/25270598 | http://purl.uniprot.org/core/author | "Yonemura S."xsd:string |
| http://purl.uniprot.org/citations/25270598 | http://purl.uniprot.org/core/author | "Yonemura S."xsd:string |
| http://purl.uniprot.org/citations/25270598 | http://purl.uniprot.org/core/author | "Era S."xsd:string |
| http://purl.uniprot.org/citations/25270598 | http://purl.uniprot.org/core/author | "Era S."xsd:string |
| http://purl.uniprot.org/citations/25270598 | http://purl.uniprot.org/core/date | "2014"xsd:gYear |
| http://purl.uniprot.org/citations/25270598 | http://purl.uniprot.org/core/date | "2014"xsd:gYear |