| http://purl.uniprot.org/citations/25271626 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/25271626 | http://www.w3.org/2000/01/rdf-schema#comment | "The lymphatic system is an important route for cancer dissemination, and lymph node metastasis (LNM) serves as a critical prognostic determinant in cancer patients. We investigated the contribution of COX-2-derived prostaglandin E2 (PGE2) in the formation of a premetastatic niche and LNM. A murine model of Lewis lung carcinoma (LLC) cell metastasis revealed that COX-2 is expressed in DCs from the early stage in the lymph node subcapsular regions, and COX-2 inhibition markedly suppressed mediastinal LNM. Stromal cell-derived factor-1 (SDF-1) was elevated in DCs before LLC cell infiltration to the lymph nodes, and a COX-2 inhibitor, an SDF-1 antagonist, and a CXCR4 neutralizing antibody all reduced LNM. Moreover, LNM was reduced in mice lacking the PGE2 receptor EP3, and stimulation of cultured DCs with an EP3 agonist increased SDF-1 production. Compared with WT CD11c+ DCs, injection of EP3-deficient CD11c+ DCs dramatically reduced accumulation of SDF-1+CD11c+ DCs in regional LNs and LNM in LLC-injected mice. Accumulation of Tregs and lymph node lymphangiogenesis, which may influence the fate of metastasized tumor cells, was also COX-2/EP3-dependent. These results indicate that DCs induce a premetastatic niche during LNM via COX-2/EP3-dependent induction of SDF-1 and suggest that inhibition of this signaling axis may be an effective strategy to suppress premetastatic niche formation and LNM."xsd:string |
| http://purl.uniprot.org/citations/25271626 | http://purl.org/dc/terms/identifier | "doi:10.1172/jci73530"xsd:string |
| http://purl.uniprot.org/citations/25271626 | http://purl.uniprot.org/core/author | "Ito Y."xsd:string |
| http://purl.uniprot.org/citations/25271626 | http://purl.uniprot.org/core/author | "Amano H."xsd:string |
| http://purl.uniprot.org/citations/25271626 | http://purl.uniprot.org/core/author | "Narumiya S."xsd:string |
| http://purl.uniprot.org/citations/25271626 | http://purl.uniprot.org/core/author | "Satoh Y."xsd:string |
| http://purl.uniprot.org/citations/25271626 | http://purl.uniprot.org/core/author | "Hosono K."xsd:string |
| http://purl.uniprot.org/citations/25271626 | http://purl.uniprot.org/core/author | "Matsui Y."xsd:string |
| http://purl.uniprot.org/citations/25271626 | http://purl.uniprot.org/core/author | "Iwabuchi K."xsd:string |
| http://purl.uniprot.org/citations/25271626 | http://purl.uniprot.org/core/author | "Kumagai Y."xsd:string |
| http://purl.uniprot.org/citations/25271626 | http://purl.uniprot.org/core/author | "Eshima K."xsd:string |
| http://purl.uniprot.org/citations/25271626 | http://purl.uniprot.org/core/author | "Kitasato H."xsd:string |
| http://purl.uniprot.org/citations/25271626 | http://purl.uniprot.org/core/author | "Majima M."xsd:string |
| http://purl.uniprot.org/citations/25271626 | http://purl.uniprot.org/core/author | "Ogawa F."xsd:string |
| http://purl.uniprot.org/citations/25271626 | http://purl.uniprot.org/core/author | "Iyoda A."xsd:string |
| http://purl.uniprot.org/citations/25271626 | http://purl.uniprot.org/core/date | "2014"xsd:gYear |
| http://purl.uniprot.org/citations/25271626 | http://purl.uniprot.org/core/name | "J Clin Invest"xsd:string |
| http://purl.uniprot.org/citations/25271626 | http://purl.uniprot.org/core/pages | "4882-4894"xsd:string |
| http://purl.uniprot.org/citations/25271626 | http://purl.uniprot.org/core/title | "Prostanoid induces premetastatic niche in regional lymph nodes."xsd:string |
| http://purl.uniprot.org/citations/25271626 | http://purl.uniprot.org/core/volume | "124"xsd:string |
| http://purl.uniprot.org/citations/25271626 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/25271626 |
| http://purl.uniprot.org/citations/25271626 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/25271626 |
| http://purl.uniprot.org/uniprot/#_G3UYL9-mappedCitation-25271626 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25271626 |
| http://purl.uniprot.org/uniprot/#_P30557-mappedCitation-25271626 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25271626 |