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| http://purl.uniprot.org/citations/25275584 | http://www.w3.org/2000/01/rdf-schema#comment | "In vitro expanded bone marrow stromal cells contain at least two populations of fibroblasts, a CD146/MCAM positive population, previously reported to be critical for establishing the stem cell niche and a CD146-negative population that expresses CUB domain-containing protein 1 (CDCP1)/CD318. Immunohistochemistry of marrow biopsies shows that clusters of CDCP1+ cells are present in discrete areas distinct from areas of fibroblasts expressing CD146. Using a stromal cell line, HS5, which approximates primary CDCP1+ stromal cells, we show that binding of an activating antibody against CDCP1 results in tyrosine-phosphorylation of CDCP1, paralleled by phosphorylation of Src Family Kinases (SFKs) Protein Kinase C delta (PKC-δ). When CDCP1 expression is knocked-down by siRNA, the expression and secretion of myelopoietic cytokines is increased. These data suggest CDCP1 expression can be used to identify a subset of marrow fibroblasts functionally distinct from CD146+ fibroblasts. Furthermore the CDCP1 protein may contribute to the defining function of these cells by regulating cytokine expression."xsd:string |
| http://purl.uniprot.org/citations/25275584 | http://purl.org/dc/terms/identifier | "doi:10.1371/journal.pone.0109304"xsd:string |
| http://purl.uniprot.org/citations/25275584 | http://purl.uniprot.org/core/author | "Iwata M."xsd:string |
| http://purl.uniprot.org/citations/25275584 | http://purl.uniprot.org/core/author | "Carter W.G."xsd:string |
| http://purl.uniprot.org/citations/25275584 | http://purl.uniprot.org/core/author | "Wayner E.A."xsd:string |
| http://purl.uniprot.org/citations/25275584 | http://purl.uniprot.org/core/author | "Torok-Storb B."xsd:string |
| http://purl.uniprot.org/citations/25275584 | http://purl.uniprot.org/core/date | "2014"xsd:gYear |
| http://purl.uniprot.org/citations/25275584 | http://purl.uniprot.org/core/name | "PLoS One"xsd:string |
| http://purl.uniprot.org/citations/25275584 | http://purl.uniprot.org/core/pages | "e109304"xsd:string |
| http://purl.uniprot.org/citations/25275584 | http://purl.uniprot.org/core/title | "CDCP1 identifies a CD146 negative subset of marrow fibroblasts involved with cytokine production."xsd:string |
| http://purl.uniprot.org/citations/25275584 | http://purl.uniprot.org/core/volume | "9"xsd:string |
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