| http://purl.uniprot.org/citations/25275953 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/25275953 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/25275953 | http://www.w3.org/2000/01/rdf-schema#comment | "Ergothioneine is a histidine thiol derivative. Its mycobacterial biosynthetic pathway has five steps (EgtA-E catalysis) with two novel reactions: a mononuclear nonheme iron enzyme (EgtB) catalyzed oxidative C-S bond formation and a PLP-mediated C-S lyase (EgtE) reaction. Our bioinformatic and biochemical analyses indicate that the fungus Neurospora crassa has a more concise ergothioneine biosynthetic pathway because its nonheme iron enzyme, Egt1, makes use of cysteine instead of γ-Glu-Cys as the substrate. Such a change of substrate preference eliminates the competition between ergothioneine and glutathione biosyntheses. In addition, we have identified the N. crassa C-S lyase (NCU11365) and reconstituted its activity in vitro, which makes the future ergothioneine production through metabolic engineering feasible."xsd:string |
| http://purl.uniprot.org/citations/25275953 | http://purl.org/dc/terms/identifier | "doi:10.1021/ol502596z"xsd:string |
| http://purl.uniprot.org/citations/25275953 | http://purl.org/dc/terms/identifier | "doi:10.1021/ol502596z"xsd:string |
| http://purl.uniprot.org/citations/25275953 | http://purl.uniprot.org/core/author | "Chen X."xsd:string |
| http://purl.uniprot.org/citations/25275953 | http://purl.uniprot.org/core/author | "Chen X."xsd:string |
| http://purl.uniprot.org/citations/25275953 | http://purl.uniprot.org/core/author | "Hu W."xsd:string |
| http://purl.uniprot.org/citations/25275953 | http://purl.uniprot.org/core/author | "Hu W."xsd:string |
| http://purl.uniprot.org/citations/25275953 | http://purl.uniprot.org/core/author | "Liu P."xsd:string |
| http://purl.uniprot.org/citations/25275953 | http://purl.uniprot.org/core/author | "Liu P."xsd:string |
| http://purl.uniprot.org/citations/25275953 | http://purl.uniprot.org/core/author | "Song H."xsd:string |
| http://purl.uniprot.org/citations/25275953 | http://purl.uniprot.org/core/author | "Song H."xsd:string |
| http://purl.uniprot.org/citations/25275953 | http://purl.uniprot.org/core/author | "Elliott S.J."xsd:string |
| http://purl.uniprot.org/citations/25275953 | http://purl.uniprot.org/core/author | "Elliott S.J."xsd:string |
| http://purl.uniprot.org/citations/25275953 | http://purl.uniprot.org/core/author | "Qin L."xsd:string |
| http://purl.uniprot.org/citations/25275953 | http://purl.uniprot.org/core/author | "Qin L."xsd:string |
| http://purl.uniprot.org/citations/25275953 | http://purl.uniprot.org/core/author | "Bak D.W."xsd:string |
| http://purl.uniprot.org/citations/25275953 | http://purl.uniprot.org/core/author | "Bak D.W."xsd:string |
| http://purl.uniprot.org/citations/25275953 | http://purl.uniprot.org/core/author | "Naowarojna N."xsd:string |
| http://purl.uniprot.org/citations/25275953 | http://purl.uniprot.org/core/author | "Naowarojna N."xsd:string |
| http://purl.uniprot.org/citations/25275953 | http://purl.uniprot.org/core/author | "Sae Her A."xsd:string |
| http://purl.uniprot.org/citations/25275953 | http://purl.uniprot.org/core/author | "Sae Her A."xsd:string |
| http://purl.uniprot.org/citations/25275953 | http://purl.uniprot.org/core/date | "2014"xsd:gYear |
| http://purl.uniprot.org/citations/25275953 | http://purl.uniprot.org/core/date | "2014"xsd:gYear |