| http://purl.uniprot.org/citations/25280793 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/25280793 | http://www.w3.org/2000/01/rdf-schema#comment | "Infection with certain pathogens induces a shift of the Th subset balance to a Th1 dominant state. This, in turn, results in the suppression of Th2 responses. We focused on the involvement of interferon regulatory factor-1 (IRF-1) in the suppression of Th2 cells during Listeria infection. We found that the inhibition of IL-4 production by Th2 cells is mediated by a soluble factor (LmSN) produced by Listeria-infected antigen-presenting cells. The inhibition is not observed with T cells from Irf1 gene-targeted mice. IRF-1 suppresses transcription of the Il4 gene in Th2 cells. Under the influence of the LmSN, IRF-1 binds to the 3' untranslated region (UTR) region of the Il4 gene and down-regulates Il4 gene transcription. Finally, we identified IL-1α and IL-1β as the mediator of the LmSN activity. Signaling through IL-1R induces the stabilization and/or nuclear translocation of IRF-1. We propose that IRF-1 functions to induce the T-cell subset shift via a novel mechanism. Under the influence of IL-1, IRF-1 translocates into the nucleus and acts on the 3'UTR region of the Il4 gene, thus inhibiting its transcription in Th2 cells. As a result, the immune system shifts predominantly to a Th1 response during Listeria infection, resulting in effective protection of the host."xsd:string |
| http://purl.uniprot.org/citations/25280793 | http://purl.org/dc/terms/identifier | "doi:10.1093/intimm/dxu092"xsd:string |
| http://purl.uniprot.org/citations/25280793 | http://purl.uniprot.org/core/author | "Asano Y."xsd:string |
| http://purl.uniprot.org/citations/25280793 | http://purl.uniprot.org/core/author | "Maruyama S."xsd:string |
| http://purl.uniprot.org/citations/25280793 | http://purl.uniprot.org/core/author | "Yamashita M."xsd:string |
| http://purl.uniprot.org/citations/25280793 | http://purl.uniprot.org/core/author | "Matsumoto A."xsd:string |
| http://purl.uniprot.org/citations/25280793 | http://purl.uniprot.org/core/author | "Kuwahara M."xsd:string |
| http://purl.uniprot.org/citations/25280793 | http://purl.uniprot.org/core/author | "Kanoh M."xsd:string |
| http://purl.uniprot.org/citations/25280793 | http://purl.uniprot.org/core/date | "2015"xsd:gYear |
| http://purl.uniprot.org/citations/25280793 | http://purl.uniprot.org/core/name | "Int Immunol"xsd:string |
| http://purl.uniprot.org/citations/25280793 | http://purl.uniprot.org/core/pages | "143-152"xsd:string |
| http://purl.uniprot.org/citations/25280793 | http://purl.uniprot.org/core/title | "A novel function of interferon regulatory factor-1: inhibition of Th2 cells by down-regulating the Il4 gene during Listeria infection."xsd:string |
| http://purl.uniprot.org/citations/25280793 | http://purl.uniprot.org/core/volume | "27"xsd:string |
| http://purl.uniprot.org/citations/25280793 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/25280793 |
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