| http://purl.uniprot.org/citations/25282160 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/25282160 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/25282160 | http://www.w3.org/2000/01/rdf-schema#comment | "Humoral autoimmunity paralleled by the accumulation of follicular helper T cells (T(FH) cells) is linked to mutation of the gene encoding the RNA-binding protein roquin-1. Here we found that T cells lacking roquin caused pathology in the lung and accumulated as cells of the T(H)17 subset of helper T cells in the lungs. Roquin inhibited T(H)17 cell differentiation and acted together with the endoribonuclease regnase-1 to repress target mRNA encoding the T(H)17 cell-promoting factors IL-6, ICOS, c-Rel, IRF4, IκBNS and IκBζ. This cooperation required binding of RNA by roquin and the nuclease activity of regnase-1. Upon recognition of antigen by the T cell antigen receptor (TCR), roquin and regnase-1 proteins were cleaved by the paracaspase MALT1. Thus, this pathway acts as a 'rheostat' by translating TCR signal strength via graded inactivation of post-transcriptional repressors and differential derepression of targets to enhance T(H)17 differentiation."xsd:string |
| http://purl.uniprot.org/citations/25282160 | http://purl.org/dc/terms/identifier | "doi:10.1038/ni.3008"xsd:string |
| http://purl.uniprot.org/citations/25282160 | http://purl.org/dc/terms/identifier | "doi:10.1038/ni.3008"xsd:string |
| http://purl.uniprot.org/citations/25282160 | http://purl.uniprot.org/core/author | "Brenner S."xsd:string |
| http://purl.uniprot.org/citations/25282160 | http://purl.uniprot.org/core/author | "Brenner S."xsd:string |
| http://purl.uniprot.org/citations/25282160 | http://purl.uniprot.org/core/author | "Fu M."xsd:string |
| http://purl.uniprot.org/citations/25282160 | http://purl.uniprot.org/core/author | "Fu M."xsd:string |
| http://purl.uniprot.org/citations/25282160 | http://purl.uniprot.org/core/author | "Kremmer E."xsd:string |
| http://purl.uniprot.org/citations/25282160 | http://purl.uniprot.org/core/author | "Kremmer E."xsd:string |
| http://purl.uniprot.org/citations/25282160 | http://purl.uniprot.org/core/author | "Schmitz I."xsd:string |
| http://purl.uniprot.org/citations/25282160 | http://purl.uniprot.org/core/author | "Schmitz I."xsd:string |
| http://purl.uniprot.org/citations/25282160 | http://purl.uniprot.org/core/author | "Weber A."xsd:string |
| http://purl.uniprot.org/citations/25282160 | http://purl.uniprot.org/core/author | "Weber A."xsd:string |
| http://purl.uniprot.org/citations/25282160 | http://purl.uniprot.org/core/author | "Martin N."xsd:string |
| http://purl.uniprot.org/citations/25282160 | http://purl.uniprot.org/core/author | "Martin N."xsd:string |
| http://purl.uniprot.org/citations/25282160 | http://purl.uniprot.org/core/author | "Hu D."xsd:string |
| http://purl.uniprot.org/citations/25282160 | http://purl.uniprot.org/core/author | "Hu D."xsd:string |
| http://purl.uniprot.org/citations/25282160 | http://purl.uniprot.org/core/author | "Geerlof A."xsd:string |
| http://purl.uniprot.org/citations/25282160 | http://purl.uniprot.org/core/author | "Geerlof A."xsd:string |
| http://purl.uniprot.org/citations/25282160 | http://purl.uniprot.org/core/author | "Heissmeyer V."xsd:string |
| http://purl.uniprot.org/citations/25282160 | http://purl.uniprot.org/core/author | "Heissmeyer V."xsd:string |
| http://purl.uniprot.org/citations/25282160 | http://purl.uniprot.org/core/author | "Krappmann D."xsd:string |
| http://purl.uniprot.org/citations/25282160 | http://purl.uniprot.org/core/author | "Krappmann D."xsd:string |