| http://purl.uniprot.org/citations/25283803 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/25283803 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/25283803 | http://www.w3.org/2000/01/rdf-schema#comment | "We conducted a comprehensive genetic analysis of the C-terminal 3rd hypervariable region of the attachment glycoprotein (G) gene in human respiratory syncytial virus subgroup A (HRSV-A) genotype ON1 (93 strains) and ancestor NA1 (125 strains). Genotype ON1 contains a unique mutation of a 72 nucleotide tandem repeat insertion (corresponding to 24 amino acids) in the hypervariable region. The Bayesian Markov chain Monte Carlo (MCMC) method was used to conduct phylogenetic analysis and a time scale for evolution. We also calculated pairwise distances (p-distances) and estimated the selective pressure. Phylogenetic analysis showed that the analyzed ON1 and NA1 strains formed 4 lineages. A strain belonging to lineage 4 of ON1 showed wide genetic divergence (p-distance, 0.072), which suggests that it might be a candidate new genotype, namely ON2. The emergence of genotype NA1 was estimated to have occurred in 2000 (95% of highest probability density, HPD; 1997-2002) and that of genotype ON1 in 2005 (95% HPD; 2000-2010) based on the time-scaled phylogenetic tree. The evolutionary rate of genotype ON1 was higher than that of ancestral genotype NA1 (6.03×10(-3) vs. 4.61×10(-3) substitutions/site/year, p<0.05). Some positive and many negative selection sites were found in both ON1 and NA1 strains. The results suggested that the new genotype ON1 is rapidly evolving with antigenic changes, leading to epidemics of HRSV infection in various countries."xsd:string |
| http://purl.uniprot.org/citations/25283803 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.meegid.2014.09.030"xsd:string |
| http://purl.uniprot.org/citations/25283803 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.meegid.2014.09.030"xsd:string |
| http://purl.uniprot.org/citations/25283803 | http://purl.uniprot.org/core/author | "Kobayashi M."xsd:string |
| http://purl.uniprot.org/citations/25283803 | http://purl.uniprot.org/core/author | "Kobayashi M."xsd:string |
| http://purl.uniprot.org/citations/25283803 | http://purl.uniprot.org/core/author | "Kuroda M."xsd:string |
| http://purl.uniprot.org/citations/25283803 | http://purl.uniprot.org/core/author | "Kuroda M."xsd:string |
| http://purl.uniprot.org/citations/25283803 | http://purl.uniprot.org/core/author | "Oishi K."xsd:string |
| http://purl.uniprot.org/citations/25283803 | http://purl.uniprot.org/core/author | "Oishi K."xsd:string |
| http://purl.uniprot.org/citations/25283803 | http://purl.uniprot.org/core/author | "Kimura H."xsd:string |
| http://purl.uniprot.org/citations/25283803 | http://purl.uniprot.org/core/author | "Kimura H."xsd:string |
| http://purl.uniprot.org/citations/25283803 | http://purl.uniprot.org/core/author | "Yoshida A."xsd:string |
| http://purl.uniprot.org/citations/25283803 | http://purl.uniprot.org/core/author | "Yoshida A."xsd:string |
| http://purl.uniprot.org/citations/25283803 | http://purl.uniprot.org/core/author | "Noda M."xsd:string |
| http://purl.uniprot.org/citations/25283803 | http://purl.uniprot.org/core/author | "Noda M."xsd:string |
| http://purl.uniprot.org/citations/25283803 | http://purl.uniprot.org/core/author | "Tsukagoshi H."xsd:string |
| http://purl.uniprot.org/citations/25283803 | http://purl.uniprot.org/core/author | "Tsukagoshi H."xsd:string |
| http://purl.uniprot.org/citations/25283803 | http://purl.uniprot.org/core/author | "Ishii H."xsd:string |
| http://purl.uniprot.org/citations/25283803 | http://purl.uniprot.org/core/author | "Ishii H."xsd:string |
| http://purl.uniprot.org/citations/25283803 | http://purl.uniprot.org/core/author | "Kozawa K."xsd:string |
| http://purl.uniprot.org/citations/25283803 | http://purl.uniprot.org/core/author | "Kozawa K."xsd:string |
| http://purl.uniprot.org/citations/25283803 | http://purl.uniprot.org/core/author | "Ishioka T."xsd:string |
| http://purl.uniprot.org/citations/25283803 | http://purl.uniprot.org/core/author | "Ishioka T."xsd:string |