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http://purl.uniprot.org/citations/25297597http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/25297597http://www.w3.org/2000/01/rdf-schema#comment"

Objective

To explore the influence of BCL6, MYC, P53 genes abnormalities can on the prognosis of diffuse large B-cell lymphoma (DLBCL), and to identify independent prognostic factors for DLBCL in order to facilitate clinical prognosis and selection of stratification treatment for the patients.

Methods

Sixty five newly diagnosed DLBCL pathological specimens were collected from 2009 to 2012. Interphase fluorescence in situ hybridization technique (I-FISH) was used to detect the status of BCL6, MYC and P53 genes. Clinical factors were combined with immunohistochemical results for multiple-factor survival analysis.

Results

The rates of BCL6 gene rearrangement, P53 gene deletion and MYC rearrangement were 21.5% (14/65), 35.4% (23/65) and 7.7% (5/65), respectively. BCL6 rearrangement group has obviously poorer overall survival (OS)(P< 0.05). COX proportional hazards model analysis showed that gender, BCL6 protein, BCL6 rearrangement, Ki67 index were prognosis factors independent of international prognostic index (IPI).

Conclusion

BCL6 can influence the prognosis of patients with DLBCL at gene and protein levels and both are independent prognostic factors for DLBCL."xsd:string
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http://purl.uniprot.org/citations/25297597http://purl.uniprot.org/core/author"Cao X."xsd:string
http://purl.uniprot.org/citations/25297597http://purl.uniprot.org/core/author"Lu C."xsd:string
http://purl.uniprot.org/citations/25297597http://purl.uniprot.org/core/author"Li Q."xsd:string
http://purl.uniprot.org/citations/25297597http://purl.uniprot.org/core/author"Wang Z."xsd:string
http://purl.uniprot.org/citations/25297597http://purl.uniprot.org/core/author"Yan F."xsd:string
http://purl.uniprot.org/citations/25297597http://purl.uniprot.org/core/author"Gao P."xsd:string
http://purl.uniprot.org/citations/25297597http://purl.uniprot.org/core/date"2014"xsd:gYear
http://purl.uniprot.org/citations/25297597http://purl.uniprot.org/core/name"Zhonghua Yi Xue Yi Chuan Xue Za Zhi"xsd:string
http://purl.uniprot.org/citations/25297597http://purl.uniprot.org/core/pages"628-631"xsd:string
http://purl.uniprot.org/citations/25297597http://purl.uniprot.org/core/title"[Significance of BCL6, MYC, P53 genes abnormalities for the prognosis of diffuse large B-cell lymphoma]."xsd:string
http://purl.uniprot.org/citations/25297597http://purl.uniprot.org/core/volume"31"xsd:string
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