| http://purl.uniprot.org/citations/25299331 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/25299331 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/25299331 | http://www.w3.org/2000/01/rdf-schema#comment | "Viral DNA sensing within the cytosol of infected cells activates type I interferon (IFN) expression. MITA/STING plays an essential role in this pathway by acting as both a sensor for the second messenger cGAMP and as an adaptor for downstream signaling components. In an expression screen for proteins that can activate the IFNB1 promoter, we identified the ER-associated protein ZDHHC1 as a positive regulator of virus-triggered, MITA/STING-dependent immune signaling. Zdhhc1(-/-) cells failed to effectively produce IFNs and other cytokines in response to infection with DNA but not RNA viruses. Zdhhc1(-/-) mice infected with the neurotropic DNA virus HSV-1 exhibited lower cytokine levels and higher virus titers in the brain, resulting in higher lethality. ZDHHC1 constitutively associated with MITA/STING and mediates dimerization/aggregation of MITA/STING and recruitment of the downstream signaling components TBK1 and IRF3. These findings support a role for ZDHHC1 in mediating MITA/STING-dependent innate immune response against DNA viruses."xsd:string |
| http://purl.uniprot.org/citations/25299331 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.chom.2014.09.006"xsd:string |
| http://purl.uniprot.org/citations/25299331 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.chom.2014.09.006"xsd:string |
| http://purl.uniprot.org/citations/25299331 | http://purl.uniprot.org/core/author | "Liu Y."xsd:string |
| http://purl.uniprot.org/citations/25299331 | http://purl.uniprot.org/core/author | "Liu Y."xsd:string |
| http://purl.uniprot.org/citations/25299331 | http://purl.uniprot.org/core/author | "Lin H."xsd:string |
| http://purl.uniprot.org/citations/25299331 | http://purl.uniprot.org/core/author | "Lin H."xsd:string |
| http://purl.uniprot.org/citations/25299331 | http://purl.uniprot.org/core/author | "Wang S."xsd:string |
| http://purl.uniprot.org/citations/25299331 | http://purl.uniprot.org/core/author | "Wang S."xsd:string |
| http://purl.uniprot.org/citations/25299331 | http://purl.uniprot.org/core/author | "Ran Y."xsd:string |
| http://purl.uniprot.org/citations/25299331 | http://purl.uniprot.org/core/author | "Ran Y."xsd:string |
| http://purl.uniprot.org/citations/25299331 | http://purl.uniprot.org/core/author | "Xiong X."xsd:string |
| http://purl.uniprot.org/citations/25299331 | http://purl.uniprot.org/core/author | "Xiong X."xsd:string |
| http://purl.uniprot.org/citations/25299331 | http://purl.uniprot.org/core/author | "Zhou Q."xsd:string |
| http://purl.uniprot.org/citations/25299331 | http://purl.uniprot.org/core/author | "Zhou Q."xsd:string |
| http://purl.uniprot.org/citations/25299331 | http://purl.uniprot.org/core/author | "Wang S.'"xsd:string |
| http://purl.uniprot.org/citations/25299331 | http://purl.uniprot.org/core/author | "Wang S.'"xsd:string |
| http://purl.uniprot.org/citations/25299331 | http://purl.uniprot.org/core/author | "Zhong B."xsd:string |
| http://purl.uniprot.org/citations/25299331 | http://purl.uniprot.org/core/author | "Zhong B."xsd:string |
| http://purl.uniprot.org/citations/25299331 | http://purl.uniprot.org/core/author | "Ye W."xsd:string |
| http://purl.uniprot.org/citations/25299331 | http://purl.uniprot.org/core/author | "Ye W."xsd:string |
| http://purl.uniprot.org/citations/25299331 | http://purl.uniprot.org/core/author | "Wang Y.Y."xsd:string |
| http://purl.uniprot.org/citations/25299331 | http://purl.uniprot.org/core/author | "Wang Y.Y."xsd:string |