| http://purl.uniprot.org/citations/25300859 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/25300859 | http://www.w3.org/2000/01/rdf-schema#comment | "Although type I IFNs play critical roles in antiviral and antitumor activity, it remains to be elucidated how type I IFNs are produced in sterile conditions of the tumor microenvironment and directly affect tumor-infiltrating immune cells. Mouse de novo gliomas show increased expression of type I IFN messages, and in mice, CD11b(+) brain-infiltrating leukocytes (BIL) are the main source of type I IFNs that are induced partially in a STING (stimulator of IFN genes)-dependent manner. Consequently, glioma-bearing Sting(Gt) (/Gt) mice showed shorter survival and lower expression levels of Ifns compared with wild-type mice. Furthermore, BILs of Sting(Gt) (/Gt) mice showed increased CD11b(+) Gr-1(+) immature myeloid suppressor and CD25(+) Foxp3(+) regulatory T cells (Treg) and decreased IFNγ-producing CD8(+) T cells. CD4(+) and CD8(+) T cells that received direct type I IFN signals showed lesser degrees of regulatory activity and increased levels of antitumor activity, respectively. Finally, intratumoral administration of a STING agonist (cyclic diguanylate monophosphate; c-di-GMP) improved the survival of glioma-bearing mice associated with enhanced type I IFN signaling, Cxcl10 and Ccl5, and T-cell migration into the brain. In combination with subcutaneous OVA peptide vaccination, c-di-GMP increased OVA-specific cytotoxicity of BILs and prolonged their survival. These data demonstrate significant contributions of STING to antitumor immunity via enhancement of type I IFN signaling in the tumor microenvironment and suggest a potential use of STING agonists for the development of effective immunotherapy, such as the combination with antigen-specific vaccinations."xsd:string |
| http://purl.uniprot.org/citations/25300859 | http://purl.org/dc/terms/identifier | "doi:10.1158/2326-6066.cir-14-0099"xsd:string |
| http://purl.uniprot.org/citations/25300859 | http://purl.uniprot.org/core/author | "David M."xsd:string |
| http://purl.uniprot.org/citations/25300859 | http://purl.uniprot.org/core/author | "Ghosh A."xsd:string |
| http://purl.uniprot.org/citations/25300859 | http://purl.uniprot.org/core/author | "Kosaka A."xsd:string |
| http://purl.uniprot.org/citations/25300859 | http://purl.uniprot.org/core/author | "Okada H."xsd:string |
| http://purl.uniprot.org/citations/25300859 | http://purl.uniprot.org/core/author | "Zhu J."xsd:string |
| http://purl.uniprot.org/citations/25300859 | http://purl.uniprot.org/core/author | "Watkins S.C."xsd:string |
| http://purl.uniprot.org/citations/25300859 | http://purl.uniprot.org/core/author | "Ohkuri T."xsd:string |
| http://purl.uniprot.org/citations/25300859 | http://purl.uniprot.org/core/author | "Sarkar S.N."xsd:string |
| http://purl.uniprot.org/citations/25300859 | http://purl.uniprot.org/core/author | "Ikeura M."xsd:string |
| http://purl.uniprot.org/citations/25300859 | http://purl.uniprot.org/core/date | "2014"xsd:gYear |
| http://purl.uniprot.org/citations/25300859 | http://purl.uniprot.org/core/name | "Cancer Immunol Res"xsd:string |
| http://purl.uniprot.org/citations/25300859 | http://purl.uniprot.org/core/pages | "1199-1208"xsd:string |
| http://purl.uniprot.org/citations/25300859 | http://purl.uniprot.org/core/title | "STING contributes to antiglioma immunity via triggering type I IFN signals in the tumor microenvironment."xsd:string |
| http://purl.uniprot.org/citations/25300859 | http://purl.uniprot.org/core/volume | "2"xsd:string |
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