| http://purl.uniprot.org/citations/25301952 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/25301952 | http://www.w3.org/2000/01/rdf-schema#comment | "The cellular response to mitogens is tightly regulated via transcriptional and post-transcriptional mechanisms to rapidly induce genes that promote proliferation and efficiently attenuate their expression to prevent malignant growth. RNase L is an endoribonuclease that mediates diverse antiproliferative activities, and tristetraprolin (TTP) is a mitogen-induced RNA-binding protein that directs the decay of proliferation-stimulatory mRNAs. In light of their roles as endogenous proliferative constraints, we examined the mechanisms and functional interactions of RNase L and TTP to attenuate a mitogenic response. Mitogen stimulation of RNase L-deficient cells significantly increased TTP transcription and the induction of other mitogen-induced mRNAs. This regulation corresponded with elevated expression of serum-response factor (SRF), a master regulator of mitogen-induced transcription. RNase L destabilized the SRF transcript and formed a complex with SRF mRNA in cells providing a mechanism by which RNase L down-regulates SRF-induced genes. TTP and RNase L proteins interacted in cells suggesting that RNase L is directed to cleave TTP-bound RNAs as a mechanism of substrate specificity. Consistent with their concerted function in RNA turnover, the absence of either RNase L or TTP stabilized SRF mRNA, and a subset of established TTP targets was also regulated by RNase L. RNase L deficiency enhanced mitogen-induced proliferation demonstrating its functional role in limiting the mitogenic response. Our findings support a model of feedback regulation in which RNase L and TTP target SRF mRNA and SRF-induced transcripts. Accordingly, meta-analysis revealed an enrichment of RNase L and TTP targets among SRF-regulated genes suggesting that the RNase L/TTP axis represents a viable target to inhibit SRF-driven proliferation in neoplastic diseases."xsd:string |
| http://purl.uniprot.org/citations/25301952 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.m114.589556"xsd:string |
| http://purl.uniprot.org/citations/25301952 | http://purl.uniprot.org/core/author | "Blackshear P.J."xsd:string |
| http://purl.uniprot.org/citations/25301952 | http://purl.uniprot.org/core/author | "Li X.L."xsd:string |
| http://purl.uniprot.org/citations/25301952 | http://purl.uniprot.org/core/author | "Ezelle H.J."xsd:string |
| http://purl.uniprot.org/citations/25301952 | http://purl.uniprot.org/core/author | "Wilson G.M."xsd:string |
| http://purl.uniprot.org/citations/25301952 | http://purl.uniprot.org/core/author | "Venkataraman T."xsd:string |
| http://purl.uniprot.org/citations/25301952 | http://purl.uniprot.org/core/author | "Hassel B.A."xsd:string |
| http://purl.uniprot.org/citations/25301952 | http://purl.uniprot.org/core/author | "Brennan-Laun S.E."xsd:string |
| http://purl.uniprot.org/citations/25301952 | http://purl.uniprot.org/core/date | "2014"xsd:gYear |
| http://purl.uniprot.org/citations/25301952 | http://purl.uniprot.org/core/name | "J Biol Chem"xsd:string |
| http://purl.uniprot.org/citations/25301952 | http://purl.uniprot.org/core/pages | "33629-33643"xsd:string |
| http://purl.uniprot.org/citations/25301952 | http://purl.uniprot.org/core/title | "RNase L attenuates mitogen-stimulated gene expression via transcriptional and post-transcriptional mechanisms to limit the proliferative response."xsd:string |
| http://purl.uniprot.org/citations/25301952 | http://purl.uniprot.org/core/volume | "289"xsd:string |
| http://purl.uniprot.org/citations/25301952 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/25301952 |
| http://purl.uniprot.org/citations/25301952 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/25301952 |
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| http://purl.uniprot.org/uniprot/#_Q1RLL8-mappedCitation-25301952 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25301952 |
| http://purl.uniprot.org/uniprot/Q1A3D9 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/25301952 |
| http://purl.uniprot.org/uniprot/Q05823 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/25301952 |
| http://purl.uniprot.org/uniprot/Q1RLL8 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/25301952 |