| http://purl.uniprot.org/citations/2530579 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/2530579 | http://www.w3.org/2000/01/rdf-schema#comment | "Interleukin 1 (IL-1) is a polypeptide hormone that mediates a broad range of biological activities and interacts with surface receptors on numerous cell types. Equilibrium binding studies have identified a class of IL-1 receptors on T cells, fibroblasts, and epithelial cells that have 2-to 5-fold higher affinity than the receptors on bone marrow cells, pre-B cells, and macrophage cell lines. Affinity cross-linking with human 125I-labeled IL-1 alpha (125I-IL-1 alpha) labels an approximately 100-kDa protein on T cells and fibroblasts and an approximately 80-kDa protein on pre-B cells and macrophage cell lines. Monoclonal and polyclonal antibodies specific for the IL-1 receptor on T cells and fibroblasts block human 125I-IL-1 alpha binding to T cells, fibroblasts, and epithelial cells but cannot block IL-1 binding to bone marrow cells, pre-B cells, and macrophages. These antibodies immunoprecipitate the IL-1 receptor-human 125I-IL-1 alpha complex from T cells and fibroblasts but not from pre-B cells and macrophage cell lines. An S1 nuclease protection assay demonstrated that T cells and fibroblasts contain identical IL-1 receptor mRNA but that pre-B cells and macrophages do not contain this receptor mRNA. Taken together, the data demonstrate that mouse T cells, fibroblasts, and epithelial cells express an identical IL-1 receptor, whereas the IL-1 receptor on pre-B cells, macrophages, and bone marrow cells represents a different gene product."xsd:string |
| http://purl.uniprot.org/citations/2530579 | http://purl.org/dc/terms/identifier | "doi:10.1073/pnas.86.20.8029"xsd:string |
| http://purl.uniprot.org/citations/2530579 | http://purl.uniprot.org/core/author | "Stern A.S."xsd:string |
| http://purl.uniprot.org/citations/2530579 | http://purl.uniprot.org/core/author | "Gubler U."xsd:string |
| http://purl.uniprot.org/citations/2530579 | http://purl.uniprot.org/core/author | "Chua A.O."xsd:string |
| http://purl.uniprot.org/citations/2530579 | http://purl.uniprot.org/core/author | "Nunes P."xsd:string |
| http://purl.uniprot.org/citations/2530579 | http://purl.uniprot.org/core/author | "Chizzonite R."xsd:string |
| http://purl.uniprot.org/citations/2530579 | http://purl.uniprot.org/core/author | "Truitt T."xsd:string |
| http://purl.uniprot.org/citations/2530579 | http://purl.uniprot.org/core/author | "Kilian P.L."xsd:string |
| http://purl.uniprot.org/citations/2530579 | http://purl.uniprot.org/core/author | "Kaffka K.L."xsd:string |
| http://purl.uniprot.org/citations/2530579 | http://purl.uniprot.org/core/author | "Lugg D.K."xsd:string |
| http://purl.uniprot.org/citations/2530579 | http://purl.uniprot.org/core/author | "Parker K.P."xsd:string |
| http://purl.uniprot.org/citations/2530579 | http://purl.uniprot.org/core/date | "1989"xsd:gYear |
| http://purl.uniprot.org/citations/2530579 | http://purl.uniprot.org/core/name | "Proc Natl Acad Sci U S A"xsd:string |
| http://purl.uniprot.org/citations/2530579 | http://purl.uniprot.org/core/pages | "8029-8033"xsd:string |
| http://purl.uniprot.org/citations/2530579 | http://purl.uniprot.org/core/title | "Two high-affinity interleukin 1 receptors represent separate gene products."xsd:string |
| http://purl.uniprot.org/citations/2530579 | http://purl.uniprot.org/core/volume | "86"xsd:string |
| http://purl.uniprot.org/citations/2530579 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/2530579 |
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| http://purl.uniprot.org/uniprot/#_Q4FK69-mappedCitation-2530579 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/2530579 |