| http://purl.uniprot.org/citations/25313070 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/25313070 | http://www.w3.org/2000/01/rdf-schema#comment | "Autocatalytic activation of an initiator caspase triggers the onset of apoptosis. In dying cells, caspase-9 activation is mediated by a multimeric adaptor complex known as the Apaf-1 apoptosome. The molecular mechanism by which caspase-9 is activated by the Apaf-1 apoptosome remains largely unknown. Here we demonstrate that the previously reported 1:1 interaction between Apaf-1 caspase recruitment domain (CARD) and caspase-9 CARD is insufficient for the activation of caspase-9. Rather, formation of a multimeric CARD:CARD assembly between Apaf-1 and caspase-9, which requires three types of distinct interfaces, underlies caspase-9 activation. Importantly, an additional surface area on the multimeric CARD assembly is essential for caspase-9 activation. Together, these findings reveal mechanistic insights into the activation of caspase-9 by the Apaf-1 apoptosome and support the induced conformation model for initiator caspase activation by adaptor complexes."xsd:string |
| http://purl.uniprot.org/citations/25313070 | http://purl.org/dc/terms/identifier | "doi:10.1073/pnas.1418000111"xsd:string |
| http://purl.uniprot.org/citations/25313070 | http://purl.uniprot.org/core/author | "Chen W."xsd:string |
| http://purl.uniprot.org/citations/25313070 | http://purl.uniprot.org/core/author | "Hu Q."xsd:string |
| http://purl.uniprot.org/citations/25313070 | http://purl.uniprot.org/core/author | "Liang Q."xsd:string |
| http://purl.uniprot.org/citations/25313070 | http://purl.uniprot.org/core/author | "Shi Y."xsd:string |
| http://purl.uniprot.org/citations/25313070 | http://purl.uniprot.org/core/author | "Wu D."xsd:string |
| http://purl.uniprot.org/citations/25313070 | http://purl.uniprot.org/core/author | "Yan Z."xsd:string |
| http://purl.uniprot.org/citations/25313070 | http://purl.uniprot.org/core/author | "Yan C."xsd:string |
| http://purl.uniprot.org/citations/25313070 | http://purl.uniprot.org/core/author | "He T."xsd:string |
| http://purl.uniprot.org/citations/25313070 | http://purl.uniprot.org/core/date | "2014"xsd:gYear |
| http://purl.uniprot.org/citations/25313070 | http://purl.uniprot.org/core/name | "Proc Natl Acad Sci U S A"xsd:string |
| http://purl.uniprot.org/citations/25313070 | http://purl.uniprot.org/core/pages | "16254-16261"xsd:string |
| http://purl.uniprot.org/citations/25313070 | http://purl.uniprot.org/core/title | "Molecular determinants of caspase-9 activation by the Apaf-1 apoptosome."xsd:string |
| http://purl.uniprot.org/citations/25313070 | http://purl.uniprot.org/core/volume | "111"xsd:string |
| http://purl.uniprot.org/citations/25313070 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/25313070 |
| http://purl.uniprot.org/citations/25313070 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/25313070 |
| http://purl.uniprot.org/uniprot/#_O14727-mappedCitation-25313070 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25313070 |
| http://purl.uniprot.org/uniprot/#_P55211-mappedCitation-25313070 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25313070 |
| http://purl.uniprot.org/uniprot/#_P99999-mappedCitation-25313070 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25313070 |
| http://purl.uniprot.org/uniprot/#_Q9Y2G2-mappedCitation-25313070 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25313070 |
| http://purl.uniprot.org/uniprot/#_Q96GX9-mappedCitation-25313070 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25313070 |
| http://purl.uniprot.org/uniprot/#_Q9NQS1-mappedCitation-25313070 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25313070 |
| http://purl.uniprot.org/uniprot/O14727 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/25313070 |