| http://purl.uniprot.org/citations/25314079 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/25314079 | http://www.w3.org/2000/01/rdf-schema#comment | "Snail is primarily known as a transcriptional repressor that induces epithelial-mesenchymal transition by suppressing adherent proteins. Emerging evidence suggests that Snail can act as an activator; however, the mechanism and biological significance are unclear. Here, we found that CREB-binding protein (CBP) is the critical factor in Snail-mediated target gene transactivation. CBP interacts with Snail and acetylates Snail at lysine 146 and lysine 187, which prevents the repressor complex formation. We further identified several Snail-activated targets, including TNF-α, which is also the upstream signal for Snail acetylation, and CCL2 and CCL5, which promote the recruitment of tumor-associated macrophages. Here, we present our results on the mechanism by which Snail induces target gene transactivation to remodel the tumor microenvironment."xsd:string |
| http://purl.uniprot.org/citations/25314079 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.ccell.2014.09.002"xsd:string |
| http://purl.uniprot.org/citations/25314079 | http://purl.uniprot.org/core/author | "Tai S.K."xsd:string |
| http://purl.uniprot.org/citations/25314079 | http://purl.uniprot.org/core/author | "Wang H.J."xsd:string |
| http://purl.uniprot.org/citations/25314079 | http://purl.uniprot.org/core/author | "Hsieh C.H."xsd:string |
| http://purl.uniprot.org/citations/25314079 | http://purl.uniprot.org/core/author | "Yang M.H."xsd:string |
| http://purl.uniprot.org/citations/25314079 | http://purl.uniprot.org/core/author | "Chou C.H."xsd:string |
| http://purl.uniprot.org/citations/25314079 | http://purl.uniprot.org/core/author | "Hsu D.S."xsd:string |
| http://purl.uniprot.org/citations/25314079 | http://purl.uniprot.org/core/author | "Chen N.J."xsd:string |
| http://purl.uniprot.org/citations/25314079 | http://purl.uniprot.org/core/author | "Chiu P.H."xsd:string |
| http://purl.uniprot.org/citations/25314079 | http://purl.uniprot.org/core/date | "2014"xsd:gYear |
| http://purl.uniprot.org/citations/25314079 | http://purl.uniprot.org/core/name | "Cancer Cell"xsd:string |
| http://purl.uniprot.org/citations/25314079 | http://purl.uniprot.org/core/pages | "534-548"xsd:string |
| http://purl.uniprot.org/citations/25314079 | http://purl.uniprot.org/core/title | "Acetylation of snail modulates the cytokinome of cancer cells to enhance the recruitment of macrophages."xsd:string |
| http://purl.uniprot.org/citations/25314079 | http://purl.uniprot.org/core/volume | "26"xsd:string |
| http://purl.uniprot.org/citations/25314079 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/25314079 |
| http://purl.uniprot.org/citations/25314079 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/25314079 |
| http://purl.uniprot.org/uniprot/#_A0A0U1RP23-mappedCitation-25314079 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25314079 |
| http://purl.uniprot.org/uniprot/#_A0A0U1RP46-mappedCitation-25314079 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25314079 |
| http://purl.uniprot.org/uniprot/#_A0A0U1RPL2-mappedCitation-25314079 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25314079 |
| http://purl.uniprot.org/uniprot/#_A0A0U1RPQ3-mappedCitation-25314079 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25314079 |
| http://purl.uniprot.org/uniprot/#_A0A0R4J210-mappedCitation-25314079 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25314079 |
| http://purl.uniprot.org/uniprot/#_A0A0U5J4W4-mappedCitation-25314079 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25314079 |
| http://purl.uniprot.org/uniprot/#_A0A0U1RQB6-mappedCitation-25314079 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25314079 |