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http://purl.uniprot.org/citations/25315972http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/25315972http://www.w3.org/2000/01/rdf-schema#comment"Melanoma-associated antigens (MAGE)-A9 has been reported to play important roles in the development of human cancers. However, the association between MAGE-A9 expression and the clinicopathological characteristics of hepatocellular carcinoma (HCC) is not well understood. The study was to detect the expression of MAGE-A9 in human HCC and investigate the association between its expression and the clinicopathological characteristics of HCC. Reverse transcription-polymerase chain reaction (RT-PCR), one-step quantitative -PCR (qPCR) and immunohistochemistry (IHC) analyses were performed to characterize the expression of MAGE-A9 in HCC cell lines and tissues. Kaplan-Meier survival and Cox regression analyses were employed to evaluate the prognosis of 100 HCC patients. The results showed that the expression of MAGE-A9 in HCC was significantly higher than that in non-cancerous cells and tissues. Moreover, the expression level of the MAGE-A9 protein in HCC was related to the pathological grade (p = 0.003), portal vein invasion (p = 0.001), distant metastasis (p = 0.022) and TNM stage (p = 0.005). Cox regression analysis further revealed that MAGE-A9 expression is an independent prognostic factor for disease-free survival (p = 0.006) and overall survival (p = 0.022). These data are the first to indicate that MAGE-A9 expression is a valuable prognostic biomarker for HCC and that high MAGE-A9 expression suggests unfavorable survival outcomes in HCC patients."xsd:string
http://purl.uniprot.org/citations/25315972http://purl.org/dc/terms/identifier"doi:10.1038/srep06625"xsd:string
http://purl.uniprot.org/citations/25315972http://purl.uniprot.org/core/author"Ding Y."xsd:string
http://purl.uniprot.org/citations/25315972http://purl.uniprot.org/core/author"Fu M."xsd:string
http://purl.uniprot.org/citations/25315972http://purl.uniprot.org/core/author"Li J."xsd:string
http://purl.uniprot.org/citations/25315972http://purl.uniprot.org/core/author"Qiu L."xsd:string
http://purl.uniprot.org/citations/25315972http://purl.uniprot.org/core/author"Tang X."xsd:string
http://purl.uniprot.org/citations/25315972http://purl.uniprot.org/core/author"Zhang W."xsd:string
http://purl.uniprot.org/citations/25315972http://purl.uniprot.org/core/author"Zhu J."xsd:string
http://purl.uniprot.org/citations/25315972http://purl.uniprot.org/core/author"Zhu Y."xsd:string
http://purl.uniprot.org/citations/25315972http://purl.uniprot.org/core/author"Ge Z."xsd:string
http://purl.uniprot.org/citations/25315972http://purl.uniprot.org/core/author"Mao Y."xsd:string
http://purl.uniprot.org/citations/25315972http://purl.uniprot.org/core/author"Xiong L."xsd:string
http://purl.uniprot.org/citations/25315972http://purl.uniprot.org/core/author"Gu X."xsd:string
http://purl.uniprot.org/citations/25315972http://purl.uniprot.org/core/author"Ni H."xsd:string
http://purl.uniprot.org/citations/25315972http://purl.uniprot.org/core/author"Zhan F."xsd:string
http://purl.uniprot.org/citations/25315972http://purl.uniprot.org/core/date"2014"xsd:gYear
http://purl.uniprot.org/citations/25315972http://purl.uniprot.org/core/name"Sci Rep"xsd:string
http://purl.uniprot.org/citations/25315972http://purl.uniprot.org/core/pages"6625"xsd:string
http://purl.uniprot.org/citations/25315972http://purl.uniprot.org/core/title"High expression of MAGE-A9 correlates with unfavorable survival in hepatocellular carcinoma."xsd:string
http://purl.uniprot.org/citations/25315972http://purl.uniprot.org/core/volume"4"xsd:string
http://purl.uniprot.org/citations/25315972http://www.w3.org/2004/02/skos/core#exactMatchhttp://purl.uniprot.org/pubmed/25315972
http://purl.uniprot.org/citations/25315972http://xmlns.com/foaf/0.1/primaryTopicOfhttps://pubmed.ncbi.nlm.nih.gov/25315972
http://purl.uniprot.org/uniprot/#_P43362-mappedCitation-25315972http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/25315972