| http://purl.uniprot.org/citations/25320243 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/25320243 | http://www.w3.org/2000/01/rdf-schema#comment | "T-cell acute lymphoblastic leukemia (T-ALL) is an aggressive form of leukemia that is mainly diagnosed in children and shows a skewed gender distribution toward males. In this study, we report somatic loss-of-function mutations in the X-linked histone H3K27me3 demethylase ubiquitously transcribed X (UTX) chromosome, in human T-ALL. Interestingly, UTX mutations were exclusively present in male T-ALL patients and allelic expression analysis revealed that UTX escapes X-inactivation in female T-ALL lymphoblasts and normal T cells. Notably, we demonstrate in vitro and in vivo that the H3K27me3 demethylase UTX functions as a bona fide tumor suppressor in T-ALL. Moreover, T-ALL driven by UTX inactivation exhibits collateral sensitivity to pharmacologic H3K27me3 inhibition. All together, our results show how a gender-specific and therapeutically relevant defect in balancing H3K27 methylation contributes to T-cell leukemogenesis."xsd:string |
| http://purl.uniprot.org/citations/25320243 | http://purl.org/dc/terms/identifier | "doi:10.1182/blood-2014-05-577270"xsd:string |
| http://purl.uniprot.org/citations/25320243 | http://purl.uniprot.org/core/author | "Fang F."xsd:string |
| http://purl.uniprot.org/citations/25320243 | http://purl.uniprot.org/core/author | "Vandenberghe P."xsd:string |
| http://purl.uniprot.org/citations/25320243 | http://purl.uniprot.org/core/author | "Speleman F."xsd:string |
| http://purl.uniprot.org/citations/25320243 | http://purl.uniprot.org/core/author | "Menten B."xsd:string |
| http://purl.uniprot.org/citations/25320243 | http://purl.uniprot.org/core/author | "Lammens T."xsd:string |
| http://purl.uniprot.org/citations/25320243 | http://purl.uniprot.org/core/author | "Rosen M."xsd:string |
| http://purl.uniprot.org/citations/25320243 | http://purl.uniprot.org/core/author | "Poppe B."xsd:string |
| http://purl.uniprot.org/citations/25320243 | http://purl.uniprot.org/core/author | "Verhasselt B."xsd:string |
| http://purl.uniprot.org/citations/25320243 | http://purl.uniprot.org/core/author | "Benoit Y."xsd:string |
| http://purl.uniprot.org/citations/25320243 | http://purl.uniprot.org/core/author | "Rondou P."xsd:string |
| http://purl.uniprot.org/citations/25320243 | http://purl.uniprot.org/core/author | "Van Roy N."xsd:string |
| http://purl.uniprot.org/citations/25320243 | http://purl.uniprot.org/core/author | "Wendel H.G."xsd:string |
| http://purl.uniprot.org/citations/25320243 | http://purl.uniprot.org/core/author | "Delabesse E."xsd:string |
| http://purl.uniprot.org/citations/25320243 | http://purl.uniprot.org/core/author | "Melnick A.M."xsd:string |
| http://purl.uniprot.org/citations/25320243 | http://purl.uniprot.org/core/author | "De Moerloose B."xsd:string |
| http://purl.uniprot.org/citations/25320243 | http://purl.uniprot.org/core/author | "Van der Meulen J."xsd:string |
| http://purl.uniprot.org/citations/25320243 | http://purl.uniprot.org/core/author | "Sanghvi V."xsd:string |
| http://purl.uniprot.org/citations/25320243 | http://purl.uniprot.org/core/author | "Matthijssens F."xsd:string |
| http://purl.uniprot.org/citations/25320243 | http://purl.uniprot.org/core/author | "Van Vlierberghe P."xsd:string |
| http://purl.uniprot.org/citations/25320243 | http://purl.uniprot.org/core/author | "Taghon T."xsd:string |
| http://purl.uniprot.org/citations/25320243 | http://purl.uniprot.org/core/author | "Durinck K."xsd:string |
| http://purl.uniprot.org/citations/25320243 | http://purl.uniprot.org/core/author | "Mavrakis K."xsd:string |