| http://purl.uniprot.org/citations/25323824 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/25323824 | http://www.w3.org/2000/01/rdf-schema#comment | "Life-threatening graft-versus-host disease (GVHD) limits the use of HLA-C-mismatched unrelated donors in transplantation. Clinicians lack criteria for donor selection when HLA-C-mismatched donors are a patient's only option for cure. We examined the role for HLA-C expression levels to identify permissible HLA-C mismatches. The median fluorescence intensity, a proxy of HLA-C expression, was assigned to each HLA-C allotype in 1975 patients and their HLA-C-mismatched unrelated transplant donors. The association of outcome with the level of expression of patients' and donors' HLA-C allotypes was evaluated in multivariable models. Increasing expression level of the patient's mismatched HLA-C allotype was associated with increased risks of grades III to IV acute GVHD, nonrelapse mortality, and mortality. Increasing expression level among HLA-C mismatches with residue 116 or residue 77/80 mismatching was associated with increased nonrelapse mortality. The immunogenicity of HLA-C mismatches in unrelated donor transplantation is influenced by the expression level of the patient's mismatched HLA-C allotype. HLA-C expression levels provide new information on mismatches that should be avoided and extend understanding of HLA-C-mediated immune responses in human disease."xsd:string |
| http://purl.uniprot.org/citations/25323824 | http://purl.org/dc/terms/identifier | "doi:10.1182/blood-2014-09-599969"xsd:string |
| http://purl.uniprot.org/citations/25323824 | http://purl.uniprot.org/core/author | "Carrington M."xsd:string |
| http://purl.uniprot.org/citations/25323824 | http://purl.uniprot.org/core/author | "Schroeder M.L."xsd:string |
| http://purl.uniprot.org/citations/25323824 | http://purl.uniprot.org/core/author | "Egeland T."xsd:string |
| http://purl.uniprot.org/citations/25323824 | http://purl.uniprot.org/core/author | "O'Huigin C."xsd:string |
| http://purl.uniprot.org/citations/25323824 | http://purl.uniprot.org/core/author | "Hsu K."xsd:string |
| http://purl.uniprot.org/citations/25323824 | http://purl.uniprot.org/core/author | "Ehninger G."xsd:string |
| http://purl.uniprot.org/citations/25323824 | http://purl.uniprot.org/core/author | "Velardi A."xsd:string |
| http://purl.uniprot.org/citations/25323824 | http://purl.uniprot.org/core/author | "Gervais T."xsd:string |
| http://purl.uniprot.org/citations/25323824 | http://purl.uniprot.org/core/author | "Petersdorf E.W."xsd:string |
| http://purl.uniprot.org/citations/25323824 | http://purl.uniprot.org/core/author | "Madrigal A."xsd:string |
| http://purl.uniprot.org/citations/25323824 | http://purl.uniprot.org/core/author | "Fischer G.F."xsd:string |
| http://purl.uniprot.org/citations/25323824 | http://purl.uniprot.org/core/author | "Tiercy J.M."xsd:string |
| http://purl.uniprot.org/citations/25323824 | http://purl.uniprot.org/core/author | "Witt C.S."xsd:string |
| http://purl.uniprot.org/citations/25323824 | http://purl.uniprot.org/core/author | "Apps R."xsd:string |
| http://purl.uniprot.org/citations/25323824 | http://purl.uniprot.org/core/author | "Malkki M."xsd:string |
| http://purl.uniprot.org/citations/25323824 | http://purl.uniprot.org/core/author | "Oudshoorn M."xsd:string |
| http://purl.uniprot.org/citations/25323824 | http://purl.uniprot.org/core/author | "Du Toit E."xsd:string |
| http://purl.uniprot.org/citations/25323824 | http://purl.uniprot.org/core/author | "Jindra P."xsd:string |
| http://purl.uniprot.org/citations/25323824 | http://purl.uniprot.org/core/author | "Cesbron A."xsd:string |
| http://purl.uniprot.org/citations/25323824 | http://purl.uniprot.org/core/author | "Ringden O."xsd:string |
| http://purl.uniprot.org/citations/25323824 | http://purl.uniprot.org/core/author | "Gooley T.A."xsd:string |
| http://purl.uniprot.org/citations/25323824 | http://purl.uniprot.org/core/author | "Horowitz M.M."xsd:string |