| http://purl.uniprot.org/citations/25330014 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/25330014 | http://www.w3.org/2000/01/rdf-schema#comment | "Natural killer (NK) cells play a role in the clearance of viral infections. Combinations of alleles at the polymorphic HLA-B locus and the NK cell surface killer immunoglobulin-like receptor locus KIR3DL1/S1 have been shown to influence time to AIDS in HIV-infected individuals and risk of seroconversion in HIV exposed seronegative (HESN) subjects. Here, we assessed time to seroconversion or duration of seronegative status in a group of 168 HIV exposed individuals, including 74 seroconverters and 94 HESN based on carriage or not of KIR3DL1/S1/HLA-B genotypes previously shown to be associated with protection from infection and/or slow time to AIDS. KIR3DL1/S1 genotyping was performed by sequence-specific primer polymerase chain reaction using two pairs of specific primers for each locus. The MHC class IB locus was typed to four-position resolution to resolve Bw4 and Bw6 alleles and the amino acid present at position 80. KIR3DL1/S1 heterozygotes became HIV infected significantly faster than KIR3DS1 homozygotes. Individuals who carried both KIR3DS1 and Bw4*80I did not remain HIV seronegative longer than those from a control group who were homozygous for HLA-Bw6 and carried no HLA-A locus Bw4 alleles Subjects who were *h/*y+B*57 showed a trend towards slower time to serconversion than those with other KIR3DL1 homozygous and KIR3DL1/S1 heterozygous genotypes. Thus, KIR3DS1 homozygosity is associated with protection from HIV infection while co-carriage of KIR3DS1 and Bw4*80I is not. The requirements for protection from HIV infection can differ from those that influence time to AIDS in HIV infected individuals."xsd:string |
| http://purl.uniprot.org/citations/25330014 | http://purl.org/dc/terms/identifier | "doi:10.1371/journal.pone.0110480"xsd:string |
| http://purl.uniprot.org/citations/25330014 | http://purl.uniprot.org/core/author | "Tan X."xsd:string |
| http://purl.uniprot.org/citations/25330014 | http://purl.uniprot.org/core/author | "Bruneau J."xsd:string |
| http://purl.uniprot.org/citations/25330014 | http://purl.uniprot.org/core/author | "Routy J.P."xsd:string |
| http://purl.uniprot.org/citations/25330014 | http://purl.uniprot.org/core/author | "Bernard N.F."xsd:string |
| http://purl.uniprot.org/citations/25330014 | http://purl.uniprot.org/core/author | "Tsoukas C.M."xsd:string |
| http://purl.uniprot.org/citations/25330014 | http://purl.uniprot.org/core/author | "Kiani Z."xsd:string |
| http://purl.uniprot.org/citations/25330014 | http://purl.uniprot.org/core/author | "Tallon B.J."xsd:string |
| http://purl.uniprot.org/citations/25330014 | http://purl.uniprot.org/core/date | "2014"xsd:gYear |
| http://purl.uniprot.org/citations/25330014 | http://purl.uniprot.org/core/name | "PLoS One"xsd:string |
| http://purl.uniprot.org/citations/25330014 | http://purl.uniprot.org/core/pages | "e110480"xsd:string |
| http://purl.uniprot.org/citations/25330014 | http://purl.uniprot.org/core/title | "Time to seroconversion in HIV-exposed subjects carrying protective versus non protective KIR3DS1/L1 and HLA-B genotypes."xsd:string |
| http://purl.uniprot.org/citations/25330014 | http://purl.uniprot.org/core/volume | "9"xsd:string |
| http://purl.uniprot.org/citations/25330014 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/25330014 |
| http://purl.uniprot.org/citations/25330014 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/25330014 |
| http://purl.uniprot.org/uniprot/#_A0A0A7C543-mappedCitation-25330014 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25330014 |
| http://purl.uniprot.org/uniprot/#_A0A0A7C548-mappedCitation-25330014 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25330014 |
| http://purl.uniprot.org/uniprot/#_A0A0A7C551-mappedCitation-25330014 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25330014 |
| http://purl.uniprot.org/uniprot/#_A0A0A7C552-mappedCitation-25330014 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25330014 |
| http://purl.uniprot.org/uniprot/#_A0A0E3DC98-mappedCitation-25330014 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25330014 |
| http://purl.uniprot.org/uniprot/#_A0A0E3DCA0-mappedCitation-25330014 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25330014 |
| http://purl.uniprot.org/uniprot/#_A0A0E3DCA1-mappedCitation-25330014 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25330014 |
| http://purl.uniprot.org/uniprot/#_A0A0G2R0N3-mappedCitation-25330014 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25330014 |