| http://purl.uniprot.org/citations/25330741 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/25330741 | http://www.w3.org/2000/01/rdf-schema#comment | "Major depressive disorder is often linked to stress. Although short-term stress is without effect in mice, prolonged stress leads to depressive-like behavior, indicating that an allostatic mechanism exists in this difference. Here we demonstrate that mice after short-term (1 h per day for 7 days) chronic restraint stress (CRS), do not display depressive-like behavior. Analysis of the hippocampus of these mice showed increased levels of neurotrophic factor-α1 (NF-α1; also known as carboxypeptidase E, CPE), concomitant with enhanced fibroblast growth factor 2 (FGF2) expression, and an increase in neurogenesis in the dentate gyrus. In contrast, after prolonged (6 h per day for 21 days) CRS, mice show decreased hippocampal NF-α1 and FGF2 levels and depressive-like responses. In NF-α1-knockout mice, hippocampal FGF2 levels and neurogenesis are reduced. These mice exhibit depressive-like behavior that is reversed by FGF2 administration. Indeed, studies in cultured hippocampal neurons reveal that NF-α1 treatment directly upregulates FGF2 expression through extracellular signal-regulated kinase-Sp1 signaling. Thus, during short-term CRS, hippocampal NF-α1 expression is upregulated and has a key role in preventing the onset of depressive-like behavior through enhanced FGF2-mediated neurogenesis. To evaluate the therapeutic potential of this pathway, we examined, rosiglitazone (Rosi), a PPARγ agonist, which has been shown to have antidepressant activity in rodents and humans. Rosi upregulates FGF2 expression in a NF-α1-dependent manner in hippocampal neurons. Mice fed Rosi show increased hippocampal NF-α1 levels and neurogenesis compared with controls, thereby indicating the antidepressant action of this drug. Development of drugs that activate the NF-α1/FGF2/neurogenesis pathway can offer a new approach to depression therapy."xsd:string |
| http://purl.uniprot.org/citations/25330741 | http://purl.org/dc/terms/identifier | "doi:10.1038/mp.2014.136"xsd:string |
| http://purl.uniprot.org/citations/25330741 | http://purl.uniprot.org/core/author | "Cheng Y."xsd:string |
| http://purl.uniprot.org/citations/25330741 | http://purl.uniprot.org/core/author | "Rodriguiz R.M."xsd:string |
| http://purl.uniprot.org/citations/25330741 | http://purl.uniprot.org/core/author | "Wetsel W.C."xsd:string |
| http://purl.uniprot.org/citations/25330741 | http://purl.uniprot.org/core/author | "Ahn S."xsd:string |
| http://purl.uniprot.org/citations/25330741 | http://purl.uniprot.org/core/author | "Aryal D.K."xsd:string |
| http://purl.uniprot.org/citations/25330741 | http://purl.uniprot.org/core/author | "Loh Y.P."xsd:string |
| http://purl.uniprot.org/citations/25330741 | http://purl.uniprot.org/core/author | "Cawley N.X."xsd:string |
| http://purl.uniprot.org/citations/25330741 | http://purl.uniprot.org/core/author | "Murthy S.R."xsd:string |
| http://purl.uniprot.org/citations/25330741 | http://purl.uniprot.org/core/author | "Lecka-Czernik B."xsd:string |
| http://purl.uniprot.org/citations/25330741 | http://purl.uniprot.org/core/author | "Senatorov V."xsd:string |
| http://purl.uniprot.org/citations/25330741 | http://purl.uniprot.org/core/author | "Thouennon E."xsd:string |
| http://purl.uniprot.org/citations/25330741 | http://purl.uniprot.org/core/date | "2015"xsd:gYear |
| http://purl.uniprot.org/citations/25330741 | http://purl.uniprot.org/core/name | "Mol Psychiatry"xsd:string |
| http://purl.uniprot.org/citations/25330741 | http://purl.uniprot.org/core/pages | "744-754"xsd:string |
| http://purl.uniprot.org/citations/25330741 | http://purl.uniprot.org/core/title | "Neurotrophic factor-alpha1 prevents stress-induced depression through enhancement of neurogenesis and is activated by rosiglitazone."xsd:string |
| http://purl.uniprot.org/citations/25330741 | http://purl.uniprot.org/core/volume | "20"xsd:string |
| http://purl.uniprot.org/citations/25330741 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/25330741 |
| http://purl.uniprot.org/citations/25330741 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/25330741 |
| http://purl.uniprot.org/uniprot/#_Q00493-mappedCitation-25330741 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25330741 |
| http://purl.uniprot.org/uniprot/#_Q543R4-mappedCitation-25330741 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25330741 |
| http://purl.uniprot.org/uniprot/Q00493 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/25330741 |
| http://purl.uniprot.org/uniprot/Q543R4 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/25330741 |