| http://purl.uniprot.org/citations/25336758 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/25336758 | http://www.w3.org/2000/01/rdf-schema#comment | "Peroxisome proliferator-activated receptor gamma coactivator 1-alpha 4 (PGC-1α4) is a protein isoform derived by alternative splicing of the PGC1α mRNA and has been shown to promote muscle hypertrophy. We show here that G protein-coupled receptor 56 (GPR56) is a transcriptional target of PGC-1α4 and is induced in humans by resistance exercise. Furthermore, the anabolic effects of PGC-1α4 in cultured murine muscle cells are dependent on GPR56 signaling, because knockdown of GPR56 attenuates PGC-1α4-induced muscle hypertrophy in vitro. Forced expression of GPR56 results in myotube hypertrophy through the expression of insulin-like growth factor 1, which is dependent on Gα12/13 signaling. A murine model of overload-induced muscle hypertrophy is associated with increased expression of both GPR56 and its ligand collagen type III, whereas genetic ablation of GPR56 expression attenuates overload-induced muscle hypertrophy and associated anabolic signaling. These data illustrate a signaling pathway through GPR56 which regulates muscle hypertrophy associated with resistance/loading-type exercise."xsd:string |
| http://purl.uniprot.org/citations/25336758 | http://purl.org/dc/terms/identifier | "doi:10.1073/pnas.1417898111"xsd:string |
| http://purl.uniprot.org/citations/25336758 | http://purl.uniprot.org/core/author | "Gygi S.P."xsd:string |
| http://purl.uniprot.org/citations/25336758 | http://purl.uniprot.org/core/author | "Jedrychowski M.P."xsd:string |
| http://purl.uniprot.org/citations/25336758 | http://purl.uniprot.org/core/author | "Nair S.K."xsd:string |
| http://purl.uniprot.org/citations/25336758 | http://purl.uniprot.org/core/author | "Wu Z."xsd:string |
| http://purl.uniprot.org/citations/25336758 | http://purl.uniprot.org/core/author | "Glass D.J."xsd:string |
| http://purl.uniprot.org/citations/25336758 | http://purl.uniprot.org/core/author | "White J.P."xsd:string |
| http://purl.uniprot.org/citations/25336758 | http://purl.uniprot.org/core/author | "Piao X."xsd:string |
| http://purl.uniprot.org/citations/25336758 | http://purl.uniprot.org/core/author | "Spiegelman B.M."xsd:string |
| http://purl.uniprot.org/citations/25336758 | http://purl.uniprot.org/core/author | "Hornberger T.A."xsd:string |
| http://purl.uniprot.org/citations/25336758 | http://purl.uniprot.org/core/author | "Ruas J.L."xsd:string |
| http://purl.uniprot.org/citations/25336758 | http://purl.uniprot.org/core/author | "Martinez-Redondo V."xsd:string |
| http://purl.uniprot.org/citations/25336758 | http://purl.uniprot.org/core/author | "Rao R.R."xsd:string |
| http://purl.uniprot.org/citations/25336758 | http://purl.uniprot.org/core/author | "Wrann C.D."xsd:string |
| http://purl.uniprot.org/citations/25336758 | http://purl.uniprot.org/core/author | "You J.S."xsd:string |
| http://purl.uniprot.org/citations/25336758 | http://purl.uniprot.org/core/date | "2014"xsd:gYear |
| http://purl.uniprot.org/citations/25336758 | http://purl.uniprot.org/core/name | "Proc Natl Acad Sci U S A"xsd:string |
| http://purl.uniprot.org/citations/25336758 | http://purl.uniprot.org/core/pages | "15756-15761"xsd:string |
| http://purl.uniprot.org/citations/25336758 | http://purl.uniprot.org/core/title | "G protein-coupled receptor 56 regulates mechanical overload-induced muscle hypertrophy."xsd:string |
| http://purl.uniprot.org/citations/25336758 | http://purl.uniprot.org/core/volume | "111"xsd:string |
| http://purl.uniprot.org/citations/25336758 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/25336758 |
| http://purl.uniprot.org/citations/25336758 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/25336758 |
| http://purl.uniprot.org/uniprot/#_A0A1D5RLB9-mappedCitation-25336758 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25336758 |