| http://purl.uniprot.org/citations/25338086 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/25338086 | http://www.w3.org/2000/01/rdf-schema#comment | "The molecular mechanisms underlying reproductive aging and menopausal age in female mammals are poorly understood. Mechanistic target of rapamycin complex 1 (mTORC1) is a central controller of cell growth and proliferation. To determine whether mTORC1 signaling in oocytes plays a direct role in physiological follicular development and fertility in female mice, we conditionally deleted the specific and essential mTORC1 component Rptor (regulatory-associated protein of mTORC1) from the oocytes of primordial follicles by using transgenic mice expressing growth differentiation factor 9 (Gdf-9) promoter-mediated Cre recombinase. We provide in vivo evidence that deletion of Rptor in the oocytes of both primordial and further-developed follicles leads to the loss of mTORC1 signaling in oocytes as indicated by loss of phosphorylation of S6K1 and 4e-bp1 at T389 and S65, respectively. However, the follicular development and fertility of mice lacking Rptor in oocytes were not affected. Mechanistically, the loss of mTORC1 signaling in Rptor-deleted mouse oocytes led to the elevation of phosphatidylinositol 3-kinase (PI3K) signaling that maintained normal follicular development and fertility. Therefore, this study shows that loss of mTORC1 signaling in oocytes triggers a compensatory activation of the PI3K signaling cascade that maintains normal ovarian follicular development and fertility."xsd:string |
| http://purl.uniprot.org/citations/25338086 | http://purl.org/dc/terms/identifier | "doi:10.1371/journal.pone.0110491"xsd:string |
| http://purl.uniprot.org/citations/25338086 | http://purl.uniprot.org/core/author | "Shen Y."xsd:string |
| http://purl.uniprot.org/citations/25338086 | http://purl.uniprot.org/core/author | "Liu K."xsd:string |
| http://purl.uniprot.org/citations/25338086 | http://purl.uniprot.org/core/author | "Adhikari D."xsd:string |
| http://purl.uniprot.org/citations/25338086 | http://purl.uniprot.org/core/author | "Brannstrom M."xsd:string |
| http://purl.uniprot.org/citations/25338086 | http://purl.uniprot.org/core/author | "Gorre N."xsd:string |
| http://purl.uniprot.org/citations/25338086 | http://purl.uniprot.org/core/author | "Lindkvist R."xsd:string |
| http://purl.uniprot.org/citations/25338086 | http://purl.uniprot.org/core/date | "2014"xsd:gYear |
| http://purl.uniprot.org/citations/25338086 | http://purl.uniprot.org/core/name | "PLoS One"xsd:string |
| http://purl.uniprot.org/citations/25338086 | http://purl.uniprot.org/core/pages | "e110491"xsd:string |
| http://purl.uniprot.org/citations/25338086 | http://purl.uniprot.org/core/title | "mTORC1 Signaling in oocytes is dispensable for the survival of primordial follicles and for female fertility."xsd:string |
| http://purl.uniprot.org/citations/25338086 | http://purl.uniprot.org/core/volume | "9"xsd:string |
| http://purl.uniprot.org/citations/25338086 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/25338086 |
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