| http://purl.uniprot.org/citations/25338755 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/25338755 | http://www.w3.org/2000/01/rdf-schema#comment | "Latent transforming growth factor-β (TGFβ) binding proteins (LTBPs) bind to inactive TGFβ in the extracellular matrix. In mice, muscular dystrophy symptoms are intensified by a genetic polymorphism that changes the hinge region of LTBP, leading to increased proteolytic susceptibility and TGFβ release. We have found that the hinge region of human LTBP4 was also readily proteolysed and that proteolysis could be blocked by an antibody to the hinge region. Transgenic mice were generated to carry a bacterial artificial chromosome encoding the human LTBP4 gene. These transgenic mice displayed larger myofibers, increased damage after muscle injury, and enhanced TGFβ signaling. In the mdx mouse model of Duchenne muscular dystrophy, the human LTBP4 transgene exacerbated muscular dystrophy symptoms and resulted in weaker muscles with an increased inflammatory infiltrate and greater LTBP4 cleavage in vivo. Blocking LTBP4 cleavage may be a therapeutic strategy to reduce TGFβ release and activity and decrease inflammation and muscle damage in muscular dystrophy."xsd:string |
| http://purl.uniprot.org/citations/25338755 | http://purl.org/dc/terms/identifier | "doi:10.1126/scitranslmed.3010018"xsd:string |
| http://purl.uniprot.org/citations/25338755 | http://purl.uniprot.org/core/author | "Molkentin J.D."xsd:string |
| http://purl.uniprot.org/citations/25338755 | http://purl.uniprot.org/core/author | "Miller T."xsd:string |
| http://purl.uniprot.org/citations/25338755 | http://purl.uniprot.org/core/author | "McNally E.M."xsd:string |
| http://purl.uniprot.org/citations/25338755 | http://purl.uniprot.org/core/author | "Barton E.R."xsd:string |
| http://purl.uniprot.org/citations/25338755 | http://purl.uniprot.org/core/author | "Smith L.R."xsd:string |
| http://purl.uniprot.org/citations/25338755 | http://purl.uniprot.org/core/author | "Ceco E."xsd:string |
| http://purl.uniprot.org/citations/25338755 | http://purl.uniprot.org/core/author | "Earley J.U."xsd:string |
| http://purl.uniprot.org/citations/25338755 | http://purl.uniprot.org/core/author | "Hadhazy M."xsd:string |
| http://purl.uniprot.org/citations/25338755 | http://purl.uniprot.org/core/author | "Bogdanovich S."xsd:string |
| http://purl.uniprot.org/citations/25338755 | http://purl.uniprot.org/core/author | "Gardner B."xsd:string |
| http://purl.uniprot.org/citations/25338755 | http://purl.uniprot.org/core/author | "DeJesus A."xsd:string |
| http://purl.uniprot.org/citations/25338755 | http://purl.uniprot.org/core/date | "2014"xsd:gYear |
| http://purl.uniprot.org/citations/25338755 | http://purl.uniprot.org/core/name | "Sci Transl Med"xsd:string |
| http://purl.uniprot.org/citations/25338755 | http://purl.uniprot.org/core/pages | "259ra144"xsd:string |
| http://purl.uniprot.org/citations/25338755 | http://purl.uniprot.org/core/title | "Targeting latent TGFbeta release in muscular dystrophy."xsd:string |
| http://purl.uniprot.org/citations/25338755 | http://purl.uniprot.org/core/volume | "6"xsd:string |
| http://purl.uniprot.org/citations/25338755 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/25338755 |
| http://purl.uniprot.org/citations/25338755 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/25338755 |
| http://purl.uniprot.org/uniprot/#_A0A0C4DH07-mappedCitation-25338755 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25338755 |
| http://purl.uniprot.org/uniprot/#_A0A023ZT56-mappedCitation-25338755 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25338755 |
| http://purl.uniprot.org/uniprot/#_A0A023ZTV5-mappedCitation-25338755 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25338755 |
| http://purl.uniprot.org/uniprot/#_A0A1Q1NN66-mappedCitation-25338755 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25338755 |