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http://purl.uniprot.org/citations/25339146http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/25339146http://www.w3.org/2000/01/rdf-schema#comment"

Purpose

The purpose of this study is to evaluate the association between variants in prostaglandin-endoperoxide synthase 1 (PTGS1), prostaglandin F (2α) receptor (PTGFR), and multidrug resistance protein 4 (MRP4) genes and intraocular pressure (IOP) response to latanoprost in Chinese patients with primary open-angle glaucoma (POAG).

Methods

The IOP response to latanoprost was evaluated by percent IOP reduction (%ΔIOP) in the treated eye with the formula %ΔIOP = (Baseline IOP values -IOP values posttreatment) / Baseline IOP values × 100 %. Polymorphisms in PTGS1 (rs3842787 and rs10306114), PTGFR (rs3753380 and rs3766355), and MRP4 (rs11568658 and rs11568668) genes were detected by direct DNA sequencing. The differences among %ΔIOP of genotypes or haplotypes were obtained by use of the Mann-Whitney U test. Association analyses were performed by multiple linear regression analysis.

Results

Latanoprost were prescribed to 63 subjects, 60 of which met the inclusion/exclusion criteria for the current study. Notably, the %ΔIOP in the rs11568658 GT heterozygous genotype was 10.4 %ΔIOP lower than that of GG homozygous wild-type on day 7 (15.7 ± 2.52 vs. 26.1 ± 2.88, P=0.003), and the corresponding results in the rs10306114 AG heterozygous genotype and AT haplotype constructed by rs3753380 and rs3766355 on day 7 were 7.2 and 10.3 %ΔIOP (P<0.05). Interestingly, similar results were also observed on day 30 (P=0.008, P=0.006, and P=0.002, respectively). Multiple regression analysis showed that heterozygous genotypes of rs10306114, rs11568658, and carrier of AT haplotype were significantly correlated with the lower %ΔIOP. On day 30, the above variations explained 9.9, 10.7, and 17.7 % of the total variability of %ΔIOP in the Chinese POAG patients, respectively.

Conclusion

rs10306114, rs3753380, rs3766355, and rs11568658 single-nucleotide polymorphisms (SNPs) correlate with a response to latanoprost treatment in patients with POAG. These SNPs may be important determinants of variability in response to latanoprost."xsd:string
http://purl.uniprot.org/citations/25339146http://purl.org/dc/terms/identifier"doi:10.1007/s00228-014-1769-8"xsd:string
http://purl.uniprot.org/citations/25339146http://purl.uniprot.org/core/author"Chen X."xsd:string
http://purl.uniprot.org/citations/25339146http://purl.uniprot.org/core/author"Hong L."xsd:string
http://purl.uniprot.org/citations/25339146http://purl.uniprot.org/core/author"Wang D."xsd:string
http://purl.uniprot.org/citations/25339146http://purl.uniprot.org/core/author"Tang J."xsd:string
http://purl.uniprot.org/citations/25339146http://purl.uniprot.org/core/author"Wang G.H."xsd:string
http://purl.uniprot.org/citations/25339146http://purl.uniprot.org/core/author"Huang Z.Y."xsd:string
http://purl.uniprot.org/citations/25339146http://purl.uniprot.org/core/author"Wu L.P."xsd:string
http://purl.uniprot.org/citations/25339146http://purl.uniprot.org/core/author"Liu F.Q."xsd:string
http://purl.uniprot.org/citations/25339146http://purl.uniprot.org/core/author"Gao L.C."xsd:string
http://purl.uniprot.org/citations/25339146http://purl.uniprot.org/core/author"Huang H.G."xsd:string
http://purl.uniprot.org/citations/25339146http://purl.uniprot.org/core/author"Shi Q.Z."xsd:string
http://purl.uniprot.org/citations/25339146http://purl.uniprot.org/core/date"2015"xsd:gYear
http://purl.uniprot.org/citations/25339146http://purl.uniprot.org/core/name"Eur J Clin Pharmacol"xsd:string
http://purl.uniprot.org/citations/25339146http://purl.uniprot.org/core/pages"43-50"xsd:string
http://purl.uniprot.org/citations/25339146http://purl.uniprot.org/core/title"Influence of PTGS1, PTGFR, and MRP4 genetic variants on intraocular pressure response to latanoprost in Chinese primary open-angle glaucoma patients."xsd:string
http://purl.uniprot.org/citations/25339146http://purl.uniprot.org/core/volume"71"xsd:string
http://purl.uniprot.org/citations/25339146http://www.w3.org/2004/02/skos/core#exactMatchhttp://purl.uniprot.org/pubmed/25339146
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